Dalip J. S. Sirinathsinghji

TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.

TL;DR: The demonstration of hypothalamic and pituitary localization of the GHS-R is consistent with its role in regulating growth hormone release and the expression of the receptor in other central and peripheral regions may implicate its involvement in additional as yet undefined physiological functions.

TL;DR: Mice generated with targeted disruptions of PS1 alleles exhibited abnormal patterning of the axial skeleton and spinal ganglia, phenotypes traced to defects in somite segmentation and differentiation, suggesting PS1 is required for the spatiotemporal expression of Notch 1 and Dll 1, which are essential for somite segmentsation and maintenance of somite borders.

TL;DR: To understand the in vivo function of APP and its processing, an APP-null mutation is generated in mice and it is shown that the APP-deficient mice exhibited a decreased locomotor activity and forelimb grip strength, indicating a compromised neuronal or muscular function.

TL;DR: This work comprehensively studied the expression of all the cloned adenosine receptors in the rat, and resolves some of the uncertainty over where these receptors might act to control physiological processes mediated byAdenosine.