O
Omar F. Khan
Researcher at University of Toronto
Publications - 62
Citations - 3985
Omar F. Khan is an academic researcher from University of Toronto. The author has contributed to research in topics: Small interfering RNA & Gene silencing. The author has an hindex of 28, co-authored 61 publications receiving 3112 citations. Previous affiliations of Omar F. Khan include University Health Network & Massachusetts Institute of Technology.
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Journal ArticleDOI
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
James E. Dahlman,Carmen M. Barnés,Omar F. Khan,Aude Thiriot,Siddharth Jhunjunwala,Taylor E. Shaw,Yiping Xing,Hendrik B. Sager,Gaurav Sahay,Lauren Speciner,Andrew Bader,Roman L. Bogorad,Hao Yin,Tim Racie,Yizhou Dong,Shan Jiang,Danielle Seedorf,Apeksha Dave,Kamaljeet Singh Sandhu,Matthew J. Webber,Tatiana Novobrantseva,Vera M. Ruda,Abigail K. R. Lytton-Jean,Christopher G. Levins,Brian T. Kalish,Dayna K. Mudge,Mario F. Perez,Ludmila Abezgauz,Partha Dutta,Lynelle P. Smith,Klaus Charisse,Mark W. Kieran,Kevin Fitzgerald,Matthias Nahrendorf,Dganit Danino,Rubin M. Tuder,Ulrich H. von Andrian,Akin Akinc,Dipak Panigrahy,Avi Schroeder,Victor Koteliansky,Robert Langer,Daniel G. Anderson +42 more
TL;DR: These nanoparticles mediate the most durable non-liver silencing reported so far and facilitate the delivery of siRNAs that modify endothelial function in mouse models of vascular permeability, emphysema, primary tumour growth and metastasis.
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
James E. Dahlman,Carmen M. Barnés,Omar F. Khan,Aude Thiriot,Siddharth Jhunjunwala,Taylor E. Shaw,Yiping Xing,Hendrik B. Sager,Gaurav Sahay,Lauren Speciner,Andrew Bader,Roman L. Bogorad,Hao Yin,Tim Racie,Yizhou Dong,Shan Jiang,Danielle Seedorf,Apeksha Dave,Kamaljeet Singh Sandhu,Matthew J. Webber,Tatiana Novobrantseva,Vera M. Ruda,Abigail K. R. Lytton-Jean,Christopher G. Levins,Brian T. Kalish,Dayna K. Mudge,Mario F. Perez,Ludmila Abezgauz,Partha Dutta,Lynelle P. Smith,Klaus Charisse,Mark W. Kieran,Kevin Fitzgerald,Matthias Nahrendorf,Dganit Danino,Rubin M. Tuder,Ulrich H. von Andrian,Akin Akinc,Dipak Panigrahy,Avi Schroeder,Victor Koteliansky,Robert Langer,Daniel G. Anderson +42 more
TL;DR: Polymeric nanoparticles made of low-molecular-weight polyamines and lipids can deliver siRNA to endothelial cells with high efficiency, thereby facilitating the simultaneous silencing of multiple endothelial genes in vivo.
Journal ArticleDOI
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
Jasdave S. Chahal,Omar F. Khan,Christopher L. Cooper,Justine S. McPartlan,Jonathan K. Tsosie,Lucas D. Tilley,Saima M. Sidik,Sebastian Lourido,Robert Langer,Sina Bavari,Hidde L. Ploegh,Daniel G. Anderson +11 more
TL;DR: In this article, the authors developed a rapid response, fully synthetic, single-dose, adjuvant-free dendrimer nanoparticle vaccine platform wherein antigens are encoded by encapsulated mRNA replicons.
Journal ArticleDOI
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure
Hendrik B. Sager,Maarten Hulsmans,Kory J. Lavine,Marina B Beltrami Moreira,Timo Heidt,Gabriel Courties,Yuan Sun,Yoshiko Iwamoto,Benoit Tricot,Omar F. Khan,James E. Dahlman,Anna Borodovsky,Kevin Fitzgerald,Daniel G. Anderson,Ralph Weissleder,Peter Libby,Filip K. Swirski,Matthias Nahrendorf +17 more
TL;DR: The number, origin, phenotype, and function of remote cardiac macrophages residing in the nonischemic myocardium in mice with chronic heart failure after coronary ligation are investigated, suggesting that myocardial failure is influenced by an altered myeloid cell repertoire.
Journal ArticleDOI
Small RNA combination therapy for lung cancer
Wen Xue,James E. Dahlman,Tuomas Tammela,Omar F. Khan,Sabina Sood,Apeksha Dave,Wenxin Cai,Leilani M. Chirino,Gillian R. Yang,Roderick T. Bronson,Denise G. Crowley,Gaurav Sahay,Avi Schroeder,Robert Langer,Daniel G. Anderson,Tyler Jacks +15 more
TL;DR: It is reported that a lipid/polymer nanoparticle can deliver small RNAs to treat autochthonous tumors in the so-called “KP” mouse model of lung cancer, and the combination of miR-34a and siRNA targeting Kras improved therapeutic responses over those observed with either small RNA alone or cisplatin-based chemotherapy, leading to tumor regression.