Soheil Feizi

TL;DR: It is shown that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease.

TL;DR: A massively parallel reporter assay (MPRA) that facilitates the systematic dissection of transcriptional regulatory elements and QSAMs from two cellular states can be combined to design enhancer variants that optimize potentially conflicting objectives, such as maximizing induced activity while minimizing basal activity.

TL;DR: This work presents a general method for inferring direct effects from an observed correlation matrix containing both direct and indirect effects, and introduces an algorithm that removes the combined effect of all indirect paths of arbitrary length in a closed-form solution by exploiting eigen-decomposition and infinite-series sums.

TL;DR: In this paper, a general method for inferring direct effects from an observed correlation matrix containing both direct and indirect effects is presented, which is the inverse of network convolution, and introduces an algorithm that removes the combined effect of all indirect paths of arbitrary length in a closed-form solution by exploiting eigendecomposition and infinite-series sums.