Zhizhuo Zhang

TL;DR: It is shown that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease.

TL;DR: In this article, the authors describe the integrative analysis of 111 reference human epigenomes generated as part of the NIH Roadmap Epigenomics Consortium, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression.

TL;DR: In conclusion, this study provides insights into transcription regulation by three-dimensional chromatin interactions for both housekeeping and cell-specific genes in human cells through widespread promoter-centered intragenic, extragenics, and intergenic interactions.

TL;DR: A link between telomerase and NF-κB, a master regulator of inflammation, is uncovered, suggesting that a feed-forward regulation between them could be the key mechanistic basis for the coexistence of chronic inflammation and sustained telomersase activity in human cancers.

TL;DR: A deterministic method called ChromSDE is presented, which applies semi-definite programming techniques to find the best structure fitting the observed data and uses golden section search to finding the correct parameter for converting the contact frequency to spatial distance and proves that the parameter of conversion from contact frequencyto spatial distance will change under different resolutions theoretically and empirically.