Soley Bjornsdottir

TL;DR: The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia.

TL;DR: The scan for FET genes in 16 Icelandic families with 75 affected individuals revealed one locus on chromosome 3q13 to which FET mapped with genome-wide significance when the data were analysed either parametrically or non-parametrically, assuming an autosomal dominant model.

TL;DR: The discovery of nine novelNRG1 exons, including six alternative 5'-exons, increasing the number of potential promoters in NRG1 from three to nine, and three of the novel 5'- exons are well conserved in syntenic rat and mouse sequences; they encode proteins with novel amino-termini, here termed types IV-VI.

TL;DR: In this paper, an association between psychiatric disorders and disorders comorbid with psychiatric disorders, and genetic markers in the 8p23 genomic region is described, and methods and surrogate markers for detecting the orientation of the Inv8p23 inversion fragment are also disclosed.