J
Jesus Sainz
Researcher at Spanish National Research Council
Publications - 30
Citations - 9263
Jesus Sainz is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 18, co-authored 30 publications receiving 8862 citations. Previous affiliations of Jesus Sainz include University of Cantabria & deCODE genetics.
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Journal ArticleDOI
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
Struan F.A. Grant,Gudmar Thorleifsson,Inga Reynisdottir,Rafil Benediktsson,Andrei Manolescu,Jesus Sainz,Agnar Helgason,Hreinn Stefansson,Valur Emilsson,Anna Helgadottir,Unnur Styrkarsdottir,Kristinn P. Magnusson,G. Bragi Walters,Ebba Palsdottir,Thorbjorg Jonsdottir,Thorunn Gudmundsdottir,Arnaldur Gylfason,Jona Saemundsdottir,Robert L. Wilensky,Muredach P. Reilly,Daniel J. Rader,Yu Z. Bagger,Claus Christiansen,Vilmundur Gudnason,Gunnar Sigurdsson,Unnur Thorsteinsdottir,Jeffrey R. Gulcher,Augustine Kong,Kari Stefansson +28 more
TL;DR: A microsatellite within intron 3 of the transcription factor 7–like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes mellitus and is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.
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A high-resolution recombination map of the human genome
Augustine Kong,Daniel F. Gudbjartsson,Jesus Sainz,Gudrun M. Jonsdottir,Sigurjon A. Gudjonsson,Bjorgvin Richardsson,Sigrun Sigurdardottir,John Barnard,Bjorn Hallbeck,Gisli Masson,Adam Shlien,Stefan T Palsson,Michael L. Frigge,Thorgeir E. Thorgeirsson,Jeffrey R. Gulcher,Kari Stefansson +15 more
TL;DR: Recombination rates are significantly correlated with both cytogenetic structures and sequence and paternal chromosomes show many differences in locations of recombination maxima, suggesting that there is some underlying component determined by both genetic and environmental factors that affects maternal recombination rates.
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Neuregulin 1 and Susceptibility to Schizophrenia
Hreinn Stefansson,Engilbert Sigurdsson,Valgerdur Steinthorsdottir,Soley Bjornsdottir,Thordur Sigmundsson,Shyamali Ghosh,J Brynjolfsson,Steinunn Gunnarsdottir,Omar Ivarsson,Thomas T. Chou,Omar Hjaltason,Birgitta Birgisdottir,Helgi Jonsson,Vala G. Gudnadottir,Elsa Gudmundsdottir,Asgeir Björnsson,Brynjolfur Ingvarsson,Andres Ingason,Sigmundur Sigfusson,Hronn Hardardottir,Richard P. Harvey,Richard P. Harvey,Donna Lai,Mingdong Zhou,Daniela Brunner,Vincent Mutel,Acuna Gonzalo,Greg Lemke,Jesus Sainz,Gardar Johannesson,Thorkell Andresson,Daniel F. Gudbjartsson,Andrei Manolescu,Michael L. Frigge,Mark E. Gurney,Augustine Kong,Jeffrey R. Gulcher,Hannes Petursson,Kari Stefansson +38 more
TL;DR: The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia.
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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke
Anna Helgadottir,Andrei Manolescu,Gudmar Thorleifsson,Solveig Gretarsdottir,Helga Jonsdottir,Unnur Thorsteinsdottir,Nilesh J. Samani,Gudmundur Gudmundsson,Struan F.A. Grant,Gudmundur Thorgeirsson,Sigurlaug Sveinbjörnsdóttir,Einar M. Valdimarsson,Stefan E Matthiasson,Halldor Johannsson,Olof Gudmundsdottir,Mark E. Gurney,Jesus Sainz,Margret Thorhallsdottir,Margret B. Andresdottir,Michael L. Frigge,Eric J. Topol,Augustine Kong,Vilmundur Gudnason,Hakon Hakonarson,Jeffrey R. Gulcher,Kari Stefansson +25 more
TL;DR: It is concluded that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
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A common inversion under selection in Europeans
Hreinn Stefansson,Agnar Helgason,Gudmar Thorleifsson,Valgerdur Steinthorsdottir,Gisli Masson,John Barnard,Adam Baker,Aslaug Jonasdottir,Andres Ingason,Vala G. Gudnadottir,Natasa Desnica,Andrew A. Hicks,Arnaldur Gylfason,Daniel F. Gudbjartsson,Gudrun M. Jonsdottir,Jesus Sainz,Kari Agnarsson,Birgitta Birgisdottir,Shyamali Ghosh,Adalheidur Olafsdottir,Jean-Baptiste Cazier,Kristleifur Kristjansson,Michael L. Frigge,Thorgeir E. Thorgeirsson,Jeffrey R. Gulcher,Augustine Kong,Kari Stefansson +26 more
TL;DR: It is shown that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers.