S
Soma Das
Researcher at University of Chicago
Publications - 162
Citations - 29990
Soma Das is an academic researcher from University of Chicago. The author has contributed to research in topics: Gene & Exome sequencing. The author has an hindex of 55, co-authored 160 publications receiving 22523 citations. Previous affiliations of Soma Das include University of Illinois at Chicago & NorthShore University HealthSystem.
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Journal ArticleDOI
Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.
Sue Richards,Nazneen Aziz,Nazneen Aziz,Sherri J. Bale,David P. Bick,Soma Das,Julie M. Gastier-Foster,Wayne W. Grody,Madhuri Hegde,Elaine Lyon,Elaine B. Spector,Karl V. Voelkerding,Heidi L. Rehm +12 more
TL;DR: Because of the increased complexity of analysis and interpretation of clinical genetic testing described in this report, the ACMG strongly recommends thatclinical molecular genetic testing should be performed in a Clinical Laboratory Improvement Amendments–approved laboratory, with results interpreted by a board-certified clinical molecular geneticist or molecular genetic pathologist or the equivalent.
Journal ArticleDOI
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.
Federico Innocenti,Samir D. Undevia,Lalitha Iyer,Peixian Chen,Soma Das,Masha Kocherginsky,Theodore Karrison,Linda Janisch,Jacqueline Ramírez,Charles M. Rudin,Everett E. Vokes,Mark J. Ratain +11 more
TL;DR: UGT1A1 genotype and total bilirubin levels are strongly associated with severe neutropenia, and could be used to identify cancer patients predisposed to the severe toxicity of irinotecan.
Journal ArticleDOI
ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007
C. Sue Richards,Sherri J. Bale,Daniel B. Bellissimo,Soma Das,Wayne W. Grody,Madhuri Hegde,Elaine Lyon,Brian E Ward +7 more
TL;DR: The ACMG strongly recommends that the clinical and technical validation of sequence variation detection be performed in a CLIA-approved laboratory and interpreted by a board-certified clinical molecular geneticist or equivalent.
Journal ArticleDOI
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
Lalitha Iyer,Soma Das,Linda Janisch,Ming Wen,Jacqueline Ramírez,Theodore Karrison,Gini F. Fleming,Everett E. Vokes,Richard L. Schilsky,Mark J. Ratain +9 more
TL;DR: It is suggested that screening for UGT1A1*28 polymorphism may identify patients with lower SN-38 glucuronidation rates and greater susceptibility to irinotecan induced gastrointestinal and bone marrow toxicity.
Journal ArticleDOI
Assuring the quality of next-generation sequencing in clinical laboratory practice
Amy S. Gargis,Lisa V. Kalman,Meredith W Berry,David P. Bick,David Dimmock,Tina Hambuch,Fei Lu,Elaine Lyon,Karl V. Voelkerding,Barbara A. Zehnbauer,Richa Agarwala,Sarah F. Bennett,Bin Chen,Ephrem L H Chin,John G. Compton,Soma Das,Daniel H. Farkas,Matthew J. Ferber,Birgit Funke,Manohar R. Furtado,Lilia Ganova-Raeva,Ute Geigenmüller,Sandra J Gunselman,Madhuri Hegde,Philip L. F. Johnson,Andrew Kasarskis,Shashikant Kulkarni,Thomas Lenk,CS Jonathan Liu,Megan Manion,Teri A. Manolio,Elaine R. Mardis,Jason D. Merker,Mangalathu S. Rajeevan,Martin G. Reese,Heidi L. Rehm,Birgitte B. Simen,Joanne M. Yeakley,Justin M. Zook,Ira M. Lubin +39 more
TL;DR: This research highlights the need to understand more fully the role of Epstein-Barr virus in infectious disease and its role in Hunter-LaSalle syndrome.