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Songke Shen

Researcher at Anhui Medical University

Publications -  15
Citations -  1339

Songke Shen is an academic researcher from Anhui Medical University. The author has contributed to research in topics: Psoriasis & Medicine. The author has an hindex of 6, co-authored 12 publications receiving 1227 citations. Previous affiliations of Songke Shen include Chinese Ministry of Education.

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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Jianwen Han, +106 more
- 30 Oct 2009 - 
TL;DR: This study not only advances the understanding of the genetic basis of SLE but also highlights the value of performing GWAS in diverse ancestral populations.
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Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Liangdan Sun, +108 more
- 01 Nov 2010 - 
TL;DR: Six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A are identified and the heterogeneity of disease susceptibility between the Chinese and European populations is highlighted.
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Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis

TL;DR: It is suggested that mevalonate kinase gene has a role in regulating calcium-induced keratinocyte differentiation and could protect keratinocytes from apoptosis induced by type A ultraviolet radiation and could help advance the understanding of DSAP pathogenesis.
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NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis

TL;DR: In vitro assay confirmed that the activation of Th1 and Th17 mediated by NFKB1 in psoriasis promoted the proliferation, migration and invasion of keratinocytes.
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Variants in SELL, MRPS36P2, TP63, DDB2, CACNA1H, ADAM19, GNAI1, CDH13 and GABRG2 interact to confer risk of acne in Chinese population.

TL;DR: In this paper, the authors investigated the best-fit association models for the single nucleotide polymorphisms (SNP) from these interacting genes, implemented logistic regression analysis in the combined sample of 2916 cases with severe acne and 4716 controls.