Sophie Godard

TL;DR: The association of the epigenetic inactivation of the DNA repair gene MGMT with better outcome in this homogenous cohort may have important implications for the design of future trials and supports efforts to deplete MGMT by O-6-benzylguanine, a noncytotoxic substrate of this enzyme.

TL;DR: It is demonstrated that human gliomas can be differentiated according to their gene expression, and found that low-grade astrocytoma have the most specific and similar expression profiles, whereas primary glioblastoma exhibit much larger variation between tumors.

TL;DR: Data suggest that MIC-1 is an important downstream mediator of p53 function, while acting itself as an intercessor of cellular stress signaling and exerting anti-tumorigenic activities.

TL;DR: Deletion of INK4a/Arf appears to keep ERK in its active, phosphorylated state insensitive to an upstream inhibitor specifically targeting EGFR/ΔEGFR(2–7), which may contribute to the cooperative tumorigenic effect selected for in human glioblastoma.

TL;DR: Correction to: Oncogene (2004) 23, 6854–6863; Figure 4 and 5 were published incorrectly.