S
Sophie Le Maout
Researcher at French Institute of Health and Medical Research
Publications - 8
Citations - 370
Sophie Le Maout is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Epithelial polarity & Apical membrane. The author has an hindex of 7, co-authored 8 publications receiving 362 citations. Previous affiliations of Sophie Le Maout include French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes.
Ricardo Madrid,Sophie Le Maout,Marie-Bénédicte Barrault,Katy Janvier,Serge Benichou,Jean Mérot +5 more
TL;DR: It is shown that two independent C‐terminal signals determine AQP4 basolateral membrane targeting in epithelial MDCK cells, and stress‐induced kinase casein kinase (CK)II phosphorylates the Ser276 immediately preceding the tyrosine motif, increasing AQp4–μ3A interaction and enhancing AQP 4–lysosomal targeting and degradation.
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Two types of K+ channels in the apical membrane of rabbit proximal tubule in primary culture.
TL;DR: The patch-clamp technique was used to investigate ionic channels in the apical membrane of rabbit proximal tubule cells in primary culture and revealed the presence of a highly selective K+ channel with a conductance of 130 pS that was blocked by barium, tetraethylammonium and Leiurus quinquestriatus scorpion venom when applied to the extracellular face of the channel.
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Basolateral membrane expression of a K+ channel, Kir 2.3, is directed by a cytoplasmic COOH-terminal domain
TL;DR: The data indicate that the basolateral sorting determinant in Kir 2.3 is composed of a unique arrangement of trafficking motifs, containing tandem, conceivably overlapping, biosynthetic targeting and PDZ-based signals.
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Fluorescent video-microscopy study of regulatory volume decrease in primary culture of rabbit proximal convoluted tubule
TL;DR: RVD in primary cultures of rabbit proximal convoluted tubules involves the stimulation of a potassium conductance via the Ca2(+)-activated maxi K+ channel and that the accompanying anion is chloride via a conductive pathway and (or) a KCl cotransport.
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Basolateral membrane targeting of a renal-epithelial inwardly rectifying potassium channel from the cortical collecting duct, CCD-IRK3, in MDCK cells
TL;DR: Cloning an inward-rectifying K channel cDNA from a cortical collecting duct cell line and studying the targeting of several different epitope-tagged CCD-IRK3 suggest that this recombinant channel may encode the small-conductance CCD basolateral K channel.