Sören Reinke

TL;DR: It is found that mutation of the Kit receptor enables robust, uniform, sustained, and serially transplantable engraftment of human HSCs in adult mice without a requirement for irradiation conditioning.

TL;DR: Results reveal non-canonical caspase-1 signaling in vivo, and loss-of-function missense mutations in CASP1 secretes higher amounts of TNF-α.

TL;DR: A low-volume human whole blood assay facilitating the measurement of caspase-1 activation and inflammasome-related gene expression upon stimulation of the NLRP3, NLRC4 or AIM2 inflammaome is optimized and validated.

TL;DR: In this article, the authors derived a biologically motivated kinetic response model based on a differential equation to estimate the damage and clearance phases of systemic inflammation in mice, using temperature-time curves obtained from LPS stimulated mice.

TL;DR: The role of procaspase-1 variants and their interaction partners during IL-1β maturation or NF-κB activation is still poorly understood.