Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo
Sören Reinke,Mary Linge,Hans H. Diebner,Hella Luksch,Silke Glage,A Gocht,Avril A. B. Robertson,Mark E. Cooper,Sigrun R. Hofmann,Ronald Naumann,Mihail Sarov,Rayk Behrendt,Axel Roers,Frank Pessler,Joachim Roesler,Angela Rösen-Wolff,Stefan Winkler +16 more
TLDR
Results reveal non-canonical caspase-1 signaling in vivo, and loss-of-function missense mutations in CASP1 secretes higher amounts of TNF-α.About:
This article is published in Cell Reports.The article was published on 2020-02-25 and is currently open access. It has received 24 citations till now. The article focuses on the topics: Caspase 1 & Inflammasome.read more
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Therapeutic modulation of inflammasome pathways
TL;DR: In this paper, the authors proposed a novel pharmacological strategy for selectively modulating inflammasome activation in pathological conditions by targeting the upstream pathway of interleukin (IL)-1β and IL-18.
Journal Article
Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death
Hiroto Kambara,Fei Liu,Xiaoyu Zhang,Xiaoyu Zhang,Peng Liu,Besnik Bajrami,Yan Teng,Li Zhao,Shiyi Zhou,Hongbo Yu,Weidong Zhou,Leslie E. Silberstein,Tao Cheng,Mingzhe Han,Yuanfu Xu,Hongbo R. Luo +15 more
TL;DR: Gasdermin D deficiency paradoxically augmented host responses to extracellular Escherichia coli, mainly by delaying neutrophil death, which established GSDMD as a negative regulator of innate immunity and a potential target for antibacterial and anti-inflammatory therapies.
Journal ArticleDOI
Inflammasome-Mediated Immunogenicity of Clinical and Experimental Vaccine Adjuvants
TL;DR: A comprehensive overview on vaccine adjuvants that are known, or suggested, to promote immunogenicity through inflammasome-mediated signalling is provided.
Journal ArticleDOI
Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity.
TL;DR: The immunological functions of RIP2 and its possible role in autoinflammation and immunity are discussed and several other proteins suggesting additional functions outside the NOD-signaling pathway are discussed.
Journal ArticleDOI
Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice.
Shanshan Li,Yinquan Fang,Yihe Zhang,Mengmeng Song,Xi-long Zhang,Xiao Ding,Hang Yao,Miaomiao Chen,Yi Sun,Jian-Hua Ding,Qin Wang,Ming Lu,Guangyu Wu,Gang Hu +13 more
TL;DR: Park et al. as mentioned in this paper showed that the function of microglial NLRP3 inflammasome in the induction of neurotoxic reactive (A1-like) astrocytes via activating neuroinflammatory caspase-1 pathway in response to chronic stress and suggests a potential therapeutic strategy for depression.
References
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Journal ArticleDOI
NIH Image to ImageJ: 25 years of image analysis
TL;DR: The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.
Journal ArticleDOI
Non-canonical inflammasome activation targets caspase-11
Nobuhiko Kayagaki,Søren Warming,Mohamed Lamkanfi,Lieselotte Vande Walle,Salina Louie,Jennifer Dong,Kim Newton,Yan Qu,Jinfeng Liu,Sherry Heldens,Juan Zhang,Wyne P. Lee,Merone Roose-Girma,Vishva M. Dixit +13 more
TL;DR: It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.
Journal ArticleDOI
A subcellular map of the human proteome
Peter Thul,Lovisa Åkesson,Mikaela Wiking,Diana Mahdessian,Aikaterini Geladaki,Hammou Ait Blal,Tove Alm,Anna Asplund,Lars Björk,Lisa M. Breckels,Anna Bäckström,Frida Danielsson,Linn Fagerberg,Jenny Fall,Laurent Gatto,Christian Gnann,Sophia Hober,Martin Hjelmare,Fredric Johansson,Sunjae Lee,Cecilia Lindskog,Jan Mulder,Claire M. Mulvey,Peter Nilsson,Per Oksvold,Johan Rockberg,Rutger Schutten,Jochen M. Schwenk,Åsa Sivertsson,Evelina Sjöstedt,Marie Skogs,Charlotte Stadler,Devin P. Sullivan,Hanna Tegel,Casper F. Winsnes,Cheng Zhang,Martin Zwahlen,Adil Mardinoglu,Fredrik Pontén,Kalle von Feilitzen,Kathryn S. Lilley,Mathias Uhlén,Emma Lundberg +42 more
TL;DR: A subcellular map of the human proteome is presented to facilitate functional exploration of individual proteins and their role in human biology and disease and integrated into existing network models of protein-protein interactions for increased accuracy.
Book
Dose-Response Analysis Using R
TL;DR: The aim of the present paper is to provide an overview of state-of-the-art dose-response analysis, both in terms of general concepts that have evolved and matured over the years and by means of concrete examples.
Journal ArticleDOI
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll,Avril A. B. Robertson,Jae Jin Chae,Sarah C. Higgins,Raúl Muñoz-Planillo,Marco Inserra,Irina Vetter,Lara S. Dungan,Brian G. Monks,Andrea Stutz,Daniel E. Croker,Mark S. Butler,Moritz Haneklaus,Caroline E. Sutton,Gabriel Núñez,Eicke Latz,Daniel L. Kastner,Kingston H. G. Mills,Seth L. Masters,Kate Schroder,Mark E. Cooper,Luke A. J. O'Neill +21 more
TL;DR: MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle–Wells syndrome, and is a potential therapeutic for NLRP3-associated syndromes, and a tool for further study of theNLRP3 inflammasome in human health and disease.