S
Stefania Crotta
Researcher at Francis Crick Institute
Publications - 42
Citations - 3295
Stefania Crotta is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 22, co-authored 39 publications receiving 2488 citations. Previous affiliations of Stefania Crotta include University of Milan & John Radcliffe Hospital.
Papers
More filters
Journal ArticleDOI
Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein
Stefania Crotta,Annalisa Stilla,Andreas Wack,Annalisa D'Andrea,Sandra Nuti,Ugo D'Oro,Marta Mosca,Franco Filliponi,R. Maurizia Brunetto,Ferruccio Bonino,Sergio Abrignani,Nicholas Valiante +11 more
TL;DR: It is reported that ligation of an HCV receptor (CD81) inhibits natural killer (NK) cells, implicate HCV-E2–mediated inhibition of NK cells as an efficient HCV evasion strategy targeting the early antiviral activities ofNK cells and allowing the virus to establish itself as a chronic infection.
Journal ArticleDOI
Pathogenic potential of interferon αβ in acute influenza infection
TL;DR: Excessive IFNαβ signalling in response to acute influenza infection can result in uncontrolled inflammation and TRAIL-DR5-mediated epithelial cell death, which may explain morbidity and has important implications for treatment of severe disease.
Journal ArticleDOI
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.
Jack Major,Stefania Crotta,Miriam Llorian,Teresa M McCabe,Hans Henrik Gad,Simon L. Priestnall,Simon L. Priestnall,Rune Hartmann,Andreas Wack +8 more
TL;DR: It is shown that IFN signaling interferes with lung repair during influenza recovery in mice, with IFN-λ driving these effects most potently, and the location, timing, and duration of IFN exposure are critical parameters underlying the success or failure of therapeutics for viral respiratory infections.
Journal ArticleDOI
Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia
Stefania Crotta,Sophia Davidson,Tanel Mahlakõiv,Christophe Desmet,Matthew R. Buckwalter,Matthew L. Albert,Peter Staeheli,Andreas Wack +7 more
TL;DR: It is shown that airway epithelia, the primary target of influenza A virus, produce both IFN I and III upon infection, and that induction of both depends on the RIG-I/MAVS pathway.
Journal ArticleDOI
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity
Amina Metidji,Sara Omenetti,Stefania Crotta,Ying Li,Emma Nye,Ellie Ross,Vivian S. W. Li,Muralidhara Rao Maradana,Chris Schiering,Brigitta Stockinger +9 more
TL;DR: Deletion of Ahr in intestinal epithelial cells results in a defective barrier and unrestricted proliferation of intestinal stem cells (ISCs), culminating in malignant transformation, and activation of AHR by dietary ligands guards the ISC niche and maintains intestinal barrier homeostasis.