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Stephan Ladisch
Researcher at Children's National Medical Center
Publications - 128
Citations - 14406
Stephan Ladisch is an academic researcher from Children's National Medical Center. The author has contributed to research in topics: Ganglioside & Langerhans cell histiocytosis. The author has an hindex of 50, co-authored 128 publications receiving 12795 citations. Previous affiliations of Stephan Ladisch include University of California, Los Angeles & George Washington University.
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Journal ArticleDOI
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
Jan-Inge Henter,AnnaCarin Horne,Maurizio Aricò,R. Maarten Egeler,Alexandra H. Filipovich,Shinsaku Imashuku,Stephan Ladisch,Kenneth L. McClain,David Webb,Jacek Winiarski,Gritta Janka +10 more
TL;DR: HLH‐2004 chemo‐immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids, and subsequent hematopoietic stem cell transplantation is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease.
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Contemporary classification of histiocytic disorders
Blaise E. Favara,Alfred C. Feller,Macro Pauli,Elaine S. Jaffe,Lawrence M. Weiss,Maurizio Aricò,Peter Bucsky,R. Maarten Egeler,Göran Elinder,Helmut Gadner,Mary V. Gresik,Jan-Inge Henter,Shinsaku Imashuku,Gritta Janka-Schaub,Ron Jaffe,Stephan Ladisch,Christian Nezelof,Jon Pritchard +17 more
TL;DR: A classification of the histiocytic disorders that primarily affect children is presented in this article, where guidelines for distinguishing the exceedingly rare malignant diseases of histiocytes from large cell lymphomas through the use of a battery of special studies are provided.
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Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation.
Jan-Inge Henter,AnnaCarin Samuelsson-Horne,Maurizio Aricò,R. Maarten Egeler,Göran Elinder,Alexandra H. Filipovich,Helmut Gadner,Shinsaku Imashuku,Diane M. Komp,Stephan Ladisch,David Webb,Gritta Janka +11 more
TL;DR: HLH-94 is very effective, allowing BMT in most patients, and survival of children with HLH has been greatly improved.
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Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.
Helena Trottestam,AnnaCarin Horne,Maurizio Aricò,R. Maarten Egeler,Alexandra H. Filipovich,Helmut Gadner,Shinsaku Imashuku,Stephan Ladisch,David Webb,Gritta Janka,Jan-Inge Henter +10 more
TL;DR: To conclude, HLH-94 chemoimmunotherapy has considerably improved outcome in HLH, and collaborative efforts are needed to further reduce early mortality, HSCT-related mortality, and neurologic late effects.
Journal ArticleDOI
Histtocytosis syndromes in children
TL;DR: The available evidence suggests that LCH and familial HLH are the result of faulty interaction between histiocytes and T-cells, causing disregulated cytokine production or recognition, and the development of more exact treatments depends crucially on basic research to identify the exact defect in LCH