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AnnaCarin Horne

Researcher at Karolinska University Hospital

Publications -  50
Citations -  8957

AnnaCarin Horne is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Macrophage activation syndrome & Hemophagocytic lymphohistiocytosis. The author has an hindex of 25, co-authored 47 publications receiving 6997 citations. Previous affiliations of AnnaCarin Horne include Boston Children's Hospital & Karolinska Institutet.

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HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

TL;DR: HLH‐2004 chemo‐immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids, and subsequent hematopoietic stem cell transplantation is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease.
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2016 Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A European league against Rheumatism/American college of Rheumatology/Paediatric rheumatology international trials organisation collaborative initiative

TL;DR: Criteria for the classification of macrophage activation syndrome (MAS) in patients with systemic juvenile idiopathic arthritis (JIA) is developed.
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Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.

TL;DR: To conclude, HLH-94 chemoimmunotherapy has considerably improved outcome in HLH, and collaborative efforts are needed to further reduce early mortality, HSCT-related mortality, and neurologic late effects.