S
Stephan R. Targan
Researcher at Cedars-Sinai Medical Center
Publications - 577
Citations - 61849
Stephan R. Targan is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Inflammatory bowel disease & Ulcerative colitis. The author has an hindex of 108, co-authored 545 publications receiving 58069 citations. Previous affiliations of Stephan R. Targan include University of Münster & Mount Sinai Hospital, Toronto.
Papers
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Journal ArticleDOI
Human NK Cells Licensed by Killer Ig Receptor Genes Have an Altered Cytokine Program That Modifies CD4+ T Cell Function
Lin Lin,Chao Ma,Bo Wei,Najib Aziz,Raja Rajalingam,Susy Yusung,Henry A. Erlich,Elizabeth A. Trachtenberg,Stephan R. Targan,Dermot P.B. McGovern,James R. Heath,James R. Heath,Jonathan Braun +12 more
TL;DR: It is shown that the “licensing” of NK cells, determined by the presence of KIR2DL3 and homozygous HLA-C1 in host genome, results in their cytokine reprogramming, which permits them to promote CD4+ T cell activation and Th17 differentiation ex vivo.
Journal ArticleDOI
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase2b Study of Ustekinumab, a Human Monoclonal Antibody to IL-12/23p40, in Patients With Moderately to Severely Active Crohn's Disease: Results Through Week 22 From the Certifi Trial
William J. Sandborn,Christopher Gasink,Long-Long Gao,Marion Blank,Jewel Johanns,Cynthia Guzzo,Bruce E. Sands,Stephen B. Hanauer,Stephan R. Targan,Paul Rutgeerts,Subrata Ghosh,Willem J.S. de Villiers,Remo Panaccione,Gordon R. Greenberg,Stefan Schreiber,Simon Lichtiger,Brian G. Feagan +16 more
TL;DR: Early Use of Azathioprine Has a Steroid Sparing Effect on Recently Diagnosed Crohn's Disease patients.
Patent
Methods of diagnosing ulcerative colitis and crohn's disease
TL;DR: In this article, the authors proposed methods of prognosing inflammatory bowel disease (IBD) in an individual by determining the presence of at least one risk genetic variant and/or one risk serological marker.
Journal ArticleDOI
Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation.
Hidetoshi Takedatsu,Kent D. Taylor,Ling Mei,Dermot P.B. McGovern,Carol J. Landers,Rivkah Gonsky,Yingzi Cong,Eric A. Vasiliauskas,Andrew Ippoliti,Charles O. Elson,Jerome I. Rotter,Stephan R. Targan +11 more
TL;DR: The results suggest that NFKB1 haplotypes induce dysregulation of innate immune responses by altering NF-κB expression, and the use of EBV-transformed lymphoblastoid cell lines to conduct phenotypic studies of genetic variation is shown.
Journal Article
A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells.
TL;DR: Evidence is presented that cultured LPMC secrete a factor which acts on preactivated T cells in concert with TNF-alpha to augment IFN-gamma production, which is independent of IL-12 and IL-18, the well-documented potentiators of IFN, and is not produced by PBMC.