S
Stephan R. Targan
Researcher at Cedars-Sinai Medical Center
Publications - 577
Citations - 61849
Stephan R. Targan is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Inflammatory bowel disease & Ulcerative colitis. The author has an hindex of 108, co-authored 545 publications receiving 58069 citations. Previous affiliations of Stephan R. Targan include University of Münster & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis.
Gil Y. Melmed,Phillip Fleshner,Ovunc Bardakcioglu,Andrew Ippoliti,Eric A. Vasiliauskas,Konstantinos A. Papadakis,Marla Dubinsky,Carol J. Landers,Jerome I. Rotter,Stephan R. Targan +9 more
TL;DR: Patients with ulcerative colitis and indeterminate colitis with a family history of Crohn’s disease or preoperative anti-Saccharomyces cerevisiae immunoglobulin-A seropositivity are more likely to be diagnosed with Crohn's disease after ileal pouch-anal anastomosis.
Journal ArticleDOI
CC Chemokine Receptor 9 Expression Defines a Subset of Peripheral Blood Lymphocytes with Mucosal T Cell Phenotype and Th1 or T-Regulatory 1 Cytokine Profile
Konstantinos A. Papadakis,Carol J. Landers,John Prehn,Elias A. Kouroumalis,Sofia T. Moreno,Jose-Carlos Gutierrez-Ramos,Martin R. Hodge,Stephan R. Targan +7 more
TL;DR: Memory subset of circulating CCR9+CD4+ T cells has characteristics of mucosal T lymphocytes and contains cells with either Th1 or T-regulatory 1 cytokine profiles, which could provide important insight into small intestinal immune-mediated diseases and oral tolerance in humans.
Journal ArticleDOI
Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases
Mirna Šimurina,Noortje de Haan,Frano Vučković,Nicholas A. Kennedy,Jerko Štambuk,David Falck,Irena Trbojević-Akmačić,Florent Clerc,Genadij Razdorov,Anna Khon,Anna Latiano,Renata D'Incà,Silvio Danese,Stephan R. Targan,Carol J. Landers,Marla Dubinsky,Harry Campbell,Vlatka Zoldoš,Iain K. Permberton,Daniel Kolarich,Daryl L. Fernandes,Evropi Theorodorou,Victoria Merrick,Daniel I. R. Spencer,Richard A. Gardner,Ray Doran,Archana Shubhakar,Ray Boyapati,Igor Rudan,Paolo Lionetti,Jasminka Krištić,Mislav Novokmet,Maja Pučić-Baković,Olga Gornik,Angelo Andriulli,Laura Cantoro,G.C. Sturniolo,Gionata Fiorino,Natalia Manetti,Ian D. Arnott,Colin L. Noble,Charlie W. Lees,Alan G. Shand,Gwo-Tzer Ho,Malcolm G. Dunlop,Lee Murphy,Jude Gibson,Louise Evenden,Nicola Wrobel,Tamara Gilchrist,Angie Fawkes,Guinevere S. M. Kammeijer,Aleksandar Vojta,Ivana Samaržija,Dora Markulin,Marija Klasić,Paula Dobrinić,Yurii S. Aulchenko,Tim van den Heuve,Daisy Jonkers,Marieke Pierik,Dermot P.B. McGovern,Vito Annese,Manfred Wuhrer,Gordan Lauc +64 more
TL;DR: associated levels of IgG Fc-glycosylation with disease (compared to controls) and its clinical features could increase the understanding of mechanisms of CD and UC pathogenesis and be used to develop diagnostics or guide treatment.
Journal ArticleDOI
Cathelicidin signaling via the Toll-like receptor protects against colitis in mice.
Hon Wai Koon,David Q. Shih,Jeremy J.W. Chen,Kyriaki Bakirtzi,Tressia C. Hing,Ivy Ka Man Law,Samantha Ho,Ryan Ichikawa,Dezheng Zhao,Hua Xu,Richard L. Gallo,Paul W. Dempsey,Genhong Cheng,Stephan R. Targan,Charalabos Pothoulakis +14 more
TL;DR: Increased expression of cathelicidin in monocytes and experimental models of colitis involves activation of TLR9-ERK signaling by bacterial DNA, which might be involved in the pathogenesis of ulcerative colitis.
Journal ArticleDOI
Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
Steven R. Brant,David T. Okou,Claire L. Simpson,Claire L. Simpson,David J. Cutler,Talin Haritunians,Jonathan P. Bradfield,Pankaj Chopra,Jarod Prince,Ferdouse Begum,Archana Kumar,Chengrui Huang,Suresh Venkateswaran,Lisa W. Datta,Zhi Wei,Kelly A. Thomas,Lisa J. Herrinton,Jan Micheal A. Klapproth,Antonio Quiros,Jenifer Seminerio,Zhenqiu Liu,Jonathan Steven Alexander,Robert N. Baldassano,Sharon Dudley-Brown,Raymond K. Cross,Themistocles Dassopoulos,Lee A. Denson,Tanvi Dhere,Gerald W. Dryden,John S. Hanson,Jason K. Hou,Sunny Z. Hussain,Jeffrey S. Hyams,Kim L. Isaacs,Howard A. Kader,Michael D. Kappelman,Jeffry Katz,Richard Kellermayer,Barbara S. Kirschner,John F. Kuemmerle,John H. Kwon,Mark Lazarev,Ellen Li,David R. Mack,Peter J. Mannon,Dedrick E. Moulton,Rodney D. Newberry,Bankole O. Osuntokun,Ashish S. Patel,Shehzad Ahmed Saeed,Stephan R. Targan,John F. Valentine,Ming-Hsi Wang,Martin Zonca,John D. Rioux,Richard H. Duerr,Mark S. Silverberg,Judy H. Cho,Hakon Hakonarson,Michael E. Zwick,Dermot P.B. McGovern,Subra Kugathasan +61 more
TL;DR: The detection of variants associated with IBD risk in only people of African descent demonstrates the importance of studying the genetics of IBD and other complex diseases in populations beyond those of European ancestry.