J
Joanne K. Fagan
Researcher at Columbia University
Publications - 16
Citations - 2727
Joanne K. Fagan is an academic researcher from Columbia University. The author has contributed to research in topics: Asthma & Odds ratio. The author has an hindex of 13, co-authored 16 publications receiving 2650 citations. Previous affiliations of Joanne K. Fagan include American Academy of Pediatrics & National Jewish Health.
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Journal ArticleDOI
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
Elliot Israel,Vernon M. Chinchilli,Jean G. Ford,Homer A. Boushey,Reuben M. Cherniack,Timothy J. Craig,Aaron Deykin,Joanne K. Fagan,John V. Fahy,James E. Fish,Monica Kraft,Susan J. Kunselman,Stephen C. Lazarus,Robert F. Lemanske,Stephen B. Liggett,Richard J. Martin,Nandita Mitra,Stephen P. Peters,Eric S. Silverman,Christine A. Sorkness,Stanley J. Szefler,Michael E. Wechsler,Scott T. Weiss,Jeffrey M. Drazen +23 more
TL;DR: Genotype at the 16th aminoacid residue of the beta2-adrenergic receptor affects the long-term response to albuterol use and Bronchodilator treatments avoiding albutersol may be appropriate for patients with the Arg/Arg genotype.
Journal ArticleDOI
Significant variability in response to inhaled corticosteroids for persistent asthma
Stanley J. Szefler,Richard J. Martin,Tonya Sharp King,Homer A. Boushey,Reuben M. Cherniack,Vernon M. Chinchilli,Timothy J. Craig,Myrna Dolovich,Jeffrey M. Drazen,Joanne K. Fagan,John V. Fahy,John V. Fahy,James E. Fish,Jean G. Ford,Elliot Israel,James P. Kiley,Monica Kraft,Stephen C. Lazarus,Robert F. Lemanske,Elizabeth A. Mauger,Stephen P. Peters,Christine A. Sorkness +21 more
TL;DR: It is possible that higher doses of ICSs are necessary to manage more severe patients or to achieve goals of therapy not evaluated in this study, such as prevention of asthma exacerbations, after a 24-week, parallel, open-label, multicenter trial.
Journal ArticleDOI
Daily versus As-Needed Corticosteroids for Mild Persistent Asthma
Homer A. Boushey,Christine A. Sorkness,Tonya S. King,Sean D. Sullivan,John V. Fahy,Stephen C. Lazarus,Vernon M. Chinchilli,Timothy J. Craig,Emily A. Dimango,Aaron Deykin,Joanne K. Fagan,James E. Fish,Jean G. Ford,Monica Kraft,Robert F. Lemanske,Frank T. Leone,Richard J. Martin,Elizabeth A. Mauger,Gene R. Pesola,Stephen P. Peters,Nancy J. Rollings,Stanley J. Szefler,Michael E. Wechsler,Elliot Israel +23 more
TL;DR: It may be possible to treat mild persistent asthma with short, intermittent courses of inhaled or oral corticosteroids taken when symptoms worsen, and further studies are required to determine whether this novel approach to treatment should be recommended.
Journal ArticleDOI
Systemic effect comparisons of six inhaled corticosteroid preparations
Richard J. Martin,Stanley J. Szefler,Vernon M. Chinchilli,Monica Kraft,Myrna Dolovich,Homer A. Boushey,Reuben M. Cherniack,Timothy J. Craig,Jeffrey M. Drazen,Joanne K. Fagan,John V. Fahy,James E. Fish,Jean G. Ford,E. Israel,Susan J. Kunselman,Stephen C. Lazarus,Robert F. Lemanske,Stephen P. Peters,Christine A. Sorkness +18 more
TL;DR: The goal of this study was to establish a reliable method to evaluate systemic bioavailability and to determine equisystemic effects (microgram dose producing equal systemic cortisol suppression) of inhaled corticosteroids (ICS) and to represent the first step in evaluation of ICS efficacy based on equis systemic effects of a given ICS.
Journal ArticleDOI
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.
Shweta Choudhry,Ngim Ung,Pedro C. Avila,Elad Ziv,Sylvette Nazario,Jesus Casal,Alfonso Torres,Jennifer D. Gorman,Keyan Salari,Jose R. Rodriguez-Santana,Monica Toscano,Jody S. Sylvia,Maria Elena Alioto,Richard A. Castro,Michael Salazar,Ivan Gomez,Joanne K. Fagan,Jorge Salas,Suzanne Clark,Craig M. Lilly,Henry Matallana,Moisés Selman,Rocio Chapela,Dean Sheppard,Scott T. Weiss,Jean G. Ford,Homer A. Boushey,Jeffrey M. Drazen,William Rodriguez-Cintron,Edwin K. Silverman,Esteban G. Burchard +30 more
TL;DR: ethnic-specific pharmacogenetic differences exist between Arg16Gly genotypes, asthma severity, and bronchodilator response in Puerto Ricans and Mexicans with asthma, and these findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and drug responsiveness.