S
Stephen Hanessian
Researcher at Université de Montréal
Publications - 764
Citations - 19319
Stephen Hanessian is an academic researcher from Université de Montréal. The author has contributed to research in topics: Total synthesis & Bicyclic molecule. The author has an hindex of 65, co-authored 754 publications receiving 18572 citations. Previous affiliations of Stephen Hanessian include Parke-Davis & University of California, Irvine.
Papers
More filters
Patent
New cyclodextrin derivatives comprising glucosidic subunits useful for targeting, grafting and delivering a molecule of interest e.g. peptide from cyclodextrin platform
TL;DR: In this paper, a new class of cyclodextrin derivatives (I) comprising glucosidic subunits of formula (a)-(c), are introduced, including R 1H or carbon chain; R 2amino group or azide; R 3OH, OR 4or halo; R 4carbon chain; and n : 4-6.
Journal ArticleDOI
The Synthesis of Enantiomerically Pure Disubstituted Aziridines and N-Alkoxy Aziridines.
TL;DR: The addition of a chloroallyl phosphonamide anion to oximes has allowed the preparation of a variety of cis-disubstituted N-alkoxy aziridines in enantiomerically pure form.
Journal ArticleDOI
Design And Synthesis Of An Azabicyclic Nucleoside Phosphoramidite For Oligonucleotide Antisense Constructs.
TL;DR: The synthesis and biophysical evaluation of an azabicycle dinucleotide with restricted γ, β, and ε torsion angles is reported, featuring the introduction of a piperidine ring that locks the conformation of the nucleoside into an RNA-type nucleic acid.
Journal ArticleDOI
A Versatile Synthesis of a β‐Turn Peptidomimetic Scaffold: An Approach Towards a Designed Model Antagonist of the Tachykinin NK‐2 Receptor.
TL;DR: In this article, a general and stereocontrolled synthesis of an azabicyclo[4.3.0]nonane amino acid template with an appended substitutent at C-5 was developed.
Journal ArticleDOI
A Novel Synthetic Route to the Hexahydrobenzofuran Subunit of the Avermectins and Milbemycins.
TL;DR: In this article, the cyclization of a bromovinyl-type appendage onto a functionalized cyclohexene carboxylic acid derivative produces the corresponding oxahydrindanes which can be transformed into hexahydrinenes (hexahydrobenzofurans) related to the title compounds.