S
Stephen Hanessian
Researcher at Université de Montréal
Publications - 764
Citations - 19319
Stephen Hanessian is an academic researcher from Université de Montréal. The author has contributed to research in topics: Total synthesis & Bicyclic molecule. The author has an hindex of 65, co-authored 754 publications receiving 18572 citations. Previous affiliations of Stephen Hanessian include Parke-Davis & University of California, Irvine.
Papers
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Journal ArticleDOI
Cyanide-Free Synthesis of Air Stable N-Substituted Li and K Cyanamide Salts from Tetrazoles. Applications toward the Synthesis of Primary and Secondary Cyanamides as Precursors to Amidines.
TL;DR: Addition of lithium organometallics to the N,N'-disubstituted cyanamides provides a new method for accessing N, N'-disubsided amidines, which are air stable white solids at room temperature.
Journal ArticleDOI
Aminoglycoside antibiotics: synthesis of 6-0-(β-D-ribofuranosyl) paromamine
Journal ArticleDOI
Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A
Jean-Baptiste Garsi,Vito Vece,Lorenzo Sernissi,Catherine Auger-Morin,Stephen Hanessian,Alison N. McCracken,Elizabeth Selwan,Cuauhtemoc Ramirez,Amogha Dahal,Nadine Ben Romdhane,Brendan T. Finicle,Aimee L. Edinger +11 more
TL;DR: A series of ether-carbon linked analogs of a constrained synthetic sphingolipid analog 3, incorporating the tricyclic neuroleptics phenoxazine and phenothiazine to represent hybrid structures with possible synergistic cytotoxic activity showed cytotoxicity and nutrient transporter down-regulation similar to the lead compound 3.
Journal ArticleDOI
Synthetic approaches to kasugamine
Stephen Hanessian,Robert Massé +1 more
TL;DR: Reactions are described that lead to an immediate, chemical precursor of kasugamine the amino-sugar component of the aminocyclitol antibiotic kasUGamycin.
Patent
Pyrrolidine derivatives, their preparation and their use as inhibitors of neuraminidases
Malken Bayrakdarian,Chen Hui-Ju,Yuanwei Chen,David A. Degoey,William J. Flosi,Vincent L. Giranda,David J. Grampovnik,Yu Gui Gu,Stephen Hanessian,Warren M. Kati,Dale J. Kempf,April Kennedy,Larry L. Klein,Krueger Allan C,Zhen Lin,Xuehong Luo,Darold L. Madigan,Clarence J. Maring,Mcdaniel Keith F,Steven W. Muchmore,Hing L. Sham,Kent D. Stewart,Vincent S. Stoll,Minghua Sun,Noah P. Tu,Frank L. Wagenaar,Wang Gary T,Sheldon Wang,Paul E. Wiedeman,Yibo Xu,Ming C. Yeung,Chen Zhao +31 more
TL;DR: Enantiomerically enriched compounds having the absolute stereochemistry of the formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof are useful for inhibiting neuraminidases from disease-causing microorganisms as mentioned in this paper.