S
Stephen Hanessian
Researcher at Université de Montréal
Publications - 764
Citations - 19319
Stephen Hanessian is an academic researcher from Université de Montréal. The author has contributed to research in topics: Total synthesis & Bicyclic molecule. The author has an hindex of 65, co-authored 754 publications receiving 18572 citations. Previous affiliations of Stephen Hanessian include Parke-Davis & University of California, Irvine.
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Journal ArticleDOI
Synthesis and biological evaluation of novel chiral non-racemic diaminoplatinum analogs based on a tetrahydropyran motif
Stephen Hanessian,Jianguo Wang +1 more
TL;DR: Mono and dihydroxy diamino tetrahydropyran derivatives, readily available from L-arabinose, were prepared and converted into the corresponding diamino cisplatinum analogs as discussed by the authors.
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Synthesis of functionally diverse and conformationally constrained polycyclic analogues of proline and prolinol.
TL;DR: Functional diversity was introduced via further manipulation of pendant groups on the original proline motif as well as on the aromatic moiety in a series of fused 1-azacyclodihydroindene derivatives with interesting topologies.
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Methodology for the polyene and related antibiotics-versatile and practical access to bifunctional all-trans polyolefinic systems
Stephen Hanessian,Maurizio Botta +1 more
TL;DR: In this paper, a method was described to assemble all-trans bifunctional polyolefinic chains based on the reaction of aldehydes with a trienic phosphorane.
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Solution and solid phase p-alkoxybenzylation of alcohols under neutral conditions
TL;DR: In this paper, primary, secondary, and tertiary alcohols can be converted to p-methoxybenzyl ethers under neutral conditions in the presence of a variety of commonly used functional and protective groups.
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Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
Stephen Hanessian,Zhihui Shao,Claudia Betschart,Jean-Michel Rondeau,Ulf Neumann,Marina Tintelnot-Blomley +5 more
TL;DR: Co-crystallization revealed an unexpected binding mode with the P3/P4 amide bond placed into the S3 pocket resulting in a new hydrogen bond interaction pattern, which resulted in highly potent BACE-1 inhibitors with selectivity over Bace-2 and cathepsin D.