S
Stephen Hanessian
Researcher at Université de Montréal
Publications - 764
Citations - 19319
Stephen Hanessian is an academic researcher from Université de Montréal. The author has contributed to research in topics: Total synthesis & Bicyclic molecule. The author has an hindex of 65, co-authored 754 publications receiving 18572 citations. Previous affiliations of Stephen Hanessian include Parke-Davis & University of California, Irvine.
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Synthesis of 1′‐Homo‐N‐nucleosides from Hexitols
TL;DR: In this paper, a new route for the synthesis of N-(1′-homo-L-gulitol)nucleosides and amino sugar analogues by nucleophilic epoxide ring-opening followed by O-heterocyclization was described.
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Structural Properties and Stereochemically Distinct Folding Preferences of 4,5‐cis and trans‐Methano‐L‐Proline Oligomers: The Shortest Crystalline PPII‐Type Helical Proline‐Derived Tetramer
TL;DR: The first example of a crystalline tetrameric proline congener to exhibit a polyproline II helical conformation is disclosed, and experimental evidence of PPII-type helical arrangement of cis-4,5-methano-L-proline oligomers is supported by theoretical calculations.
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Design and synthesis of sialyl Lex mimetics based on carbocyclic scaffolds derived from (−) quinic acid
Stephen Hanessian,Gurijala V. Reddy,Hoan K. Huynh,Jingwen Pan,Silvana Pedatella,Beat Ernst,Hartmuth C. Kolb +6 more
TL;DR: In this article, the synthesis of sialyl Lewisx mimetic anologs in which the d -glucosamine, d -galactose, and sialic acid residues are replaced individually with appropriate glycomimetics is described.
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Total synthesis of polyoximic acid
Stephen Hanessian,Jian-Min Fu +1 more
TL;DR: The structure and stereochemistry of polyoximic acid, a degradation product from polyoxins, was originally designated as trans-3-ethylidene-L-azetidine-2-carboxylic acid as discussed by the authors.
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Robust polymeric nanoparticles for the delivery of aminoglycoside antibiotics using carboxymethyldextran-b-poly(ethyleneglycols) lightly grafted with n-dodecyl groups
TL;DR: The aminoglycosides were released from the n-dodecyl-CMD-PEG micelles in a pharmacologically active form as indicated by their ability to kill test micro-organisms in culture.