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Stephen Hanessian
Researcher at Université de Montréal
Publications - 764
Citations - 19319
Stephen Hanessian is an academic researcher from Université de Montréal. The author has contributed to research in topics: Total synthesis & Bicyclic molecule. The author has an hindex of 65, co-authored 754 publications receiving 18572 citations. Previous affiliations of Stephen Hanessian include Parke-Davis & University of California, Irvine.
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The stereocontrolled synthesis of enantiopure α-methano heterocycles and constrained amino acid analogs
TL;DR: In this article, the addition of trimethylstannyl radicals to acrylate and acrylamide derivatives that contain olefinic groups leads to the corresponding lactones and lactams with good to excellent stereochemical control.
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Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA.
TL;DR: Analogues of suberoylanilide hydroxamic acid (SAHA) were prepared by replacing the Zn-binding group with squaric acid, N-hydroxyurea, and 4-hydroxymethyl oxazoline units, also varying the length of the aliphatic chain.
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Total synthesis and stereochemical identity of the C18H32O5 degradation product from boromycin
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A highly convergent and enantiospecific synthesis of acyclic subunits of ionomycin from a single chiral progenitor
Stephen Hanessian,P. J. Murray +1 more
TL;DR: The C2-C10 and C11-C22 subunits of ionomycin were synthesized from a chiron derived from L-glutamic acid or D-ribonolactone as mentioned in this paper.
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Probing the functional requirements of the l-haba side-chain of amikacin—synthesis, 16S A-site rRNA binding, and antibacterial activity
TL;DR: The l-amino group in amikacin was acylated with a variety of 2-hydroxy aminocarboxylic acids to probe the effect of acylation on ribosomal binding and antibacterial activity.