S
Stephen Hanessian
Researcher at Université de Montréal
Publications - 764
Citations - 19319
Stephen Hanessian is an academic researcher from Université de Montréal. The author has contributed to research in topics: Total synthesis & Bicyclic molecule. The author has an hindex of 65, co-authored 754 publications receiving 18572 citations. Previous affiliations of Stephen Hanessian include Parke-Davis & University of California, Irvine.
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On the stereochemical divergence in the conjugate addition of lithium dimethylcuprate/trimethylsilyl chloride to γ-alkoxy and γ-ureido α,β-unsaturated esters
Stephen Hanessian,Kenzo Sumi +1 more
TL;DR: In this paper, a comparative study was made of chiral nonracemic γ-alkoxy and γureido-α,β-unsaturated esters with lithium dimethylcuprate in the presence of trimethylsilyl chloride.
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Enantioselective allylation of α-ketoester oximes with an external chiral ligand: Asymmetric synthesis of allylglycines and allylalanine
Stephen Hanessian,Rui-Yang Yang +1 more
TL;DR: A highly enantioselective allylation of oximes of α-ketoesters is described with phenyl substituted chiral bis(oxazoline) as external ligand of allylzinc reagents to provide efficient and convenient access to N-benzyloxy allylglycine, allyl glycine and chain substituted variants with high enantiomeric purities.
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Synthesis of diversely functionalized indolizidinones and related bicyclic lactams using intramolecular Grubbs olefin metathesis and Dieckmann condensation.
TL;DR: Bicyclic 1-aza-2-oxo ring systems with versatile functionality were synthesized from the Grubbs Olefin metathesis of appropriate olefinic precursors, starting with l-pyroglutamic acid.
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Total Synthesis and Stereochemical Confirmation of Manassantin A, B, and B1
TL;DR: Stereocontrolled total syntheses of manassantins A, B, and B1 and saucerneol are described for the first time based on a novel cycloetherification of end-differentiated benzylic alcohols as a common intermediate.
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Design and synthesis of a cephalosporin–carboplatinum prodrug activatable by a β-lactamase
Stephen Hanessian,Jianguo Wang +1 more
TL;DR: The design and syntheses of two cephalosporin–carboplatinum prodrugs that can be released by a β-lactamase are described and these notions provide a new approach to the use of platinum complexes for antitumor therapy.