Csilla Várnai

TL;DR: The clinical and demographic characteristics and COVID-19 outcomes in patients with cancer appear to be principally driven by age, gender, and comorbidities.

TL;DR: This work uses promoter capture Hi-C to identify interacting regions of 31,253 promoters in 17 human primary hematopoietic cell types and shows that promoter interactions are highly cell type specific and enriched for links between active promoters and epigenetically marked enhancers.

TL;DR: It is shown that cohesin suppresses compartments but is required for TADs and loops, that CTCF defines their boundaries, and that the cohes in unloading factor WAPL and its PDS5 binding partners control the length of loops.

TL;DR: It is shown that chromosomal compartments, topological-associated domains (TADs), contact insulation and long-range loops, all defined by bulk Hi-C maps, are governed by distinct cell-cycle dynamics, while loops are generally stable from G1 to S and G2 phase.

TL;DR: This study compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project between March 18 and May 8, 2020 with a parallel non-COVID-19 UK cancer control population, and analyzed the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 prevalence and the case–fatality rate during hospital admission.