S
Stuart Smith
Researcher at Children's Hospital Oakland Research Institute
Publications - 75
Citations - 6640
Stuart Smith is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: Fatty acid synthase & Acyl carrier protein. The author has an hindex of 40, co-authored 75 publications receiving 6328 citations. Previous affiliations of Stuart Smith include University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine.
TL;DR: The results suggest that the role of the Cys --> Gln beta-ketoacyl synthases found in the loading domains of some modular polyketide synthases likely is to act as malonyl, or methylmalonyL, decarboxylases that provide a source of primer for the chain extension reactions catalyzed by associated modules containing fully competent beta- ketoacyL synthases.
Journal ArticleDOI
Structural and functional organization of the animal fatty acid synthase.
TL;DR: A revised model for the fatty acid synthase is suggested in which the two polypeptides are oriented such that head-to-tail contacts are formed both between and within subunits.
Journal ArticleDOI
The animal fatty acid synthase: one gene, one polypeptide, seven enzymes.
TL;DR: The animal fatty acid synthase comprises two multifunctional polypeptide chains, each containing seven discrete functional domains, juxtaposed head‐to‐tail such that two separate centers for fatty acid assembly are formed at the subunit interface.
Journal ArticleDOI
The type I fatty acid and polyketide synthases: a tale of two megasynthases.
Stuart Smith,Shiou-Chuan Tsai +1 more
TL;DR: This review chronicles the synergistic growth of the fields of fatty acid and polyketide synthesis over the last century and the potential of the basic design has been exploited to the full for the elaboration of a wide range of secondary metabolites of extraordinary structural diversity.
Journal ArticleDOI
Rfx6 directs islet formation and insulin production in mice and humans
Stuart Smith,Hui-Qi Qu,Nadine Taleb,Nina Kishimoto,David W. Scheel,Yang Lu,Ann-Marie Patch,Rosemary Grabs,Juehu Wang,Francis C. Lynn,Francis C. Lynn,Takeshi Miyatsuka,John J. Mitchell,Rina Seerke,Julie Désir,Serge Vanden Eijnden,Marc Abramowicz,Nadine Kacet,Jacques Weill,Marie Éve Renard,Mattia Gentile,Inger Hansen,Ken Dewar,Andrew T. Hattersley,Rennian Wang,Maria E. Wilson,Jeffrey D. Johnson,Constantin Polychronakos,Michael S. German +28 more
TL;DR: It is shown that the transcription factor Rfx6 directs islet cell differentiation downstream of Neurog3, a unique position for RFX6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans.