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Sujitha Duggimpudi
Researcher at University of Düsseldorf
Publications - 6
Citations - 531
Sujitha Duggimpudi is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Gene knockdown & RNA-binding protein. The author has an hindex of 5, co-authored 6 publications receiving 476 citations.
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Journal ArticleDOI
RNA targets of wild-type and mutant FET family proteins
Jessica I. Hoell,Erik Larsson,Simon Runge,Jeffrey Nusbaum,Sujitha Duggimpudi,Thalia A. Farazi,Markus Hafner,Arndt Borkhardt,Chris Sander,Thomas Tuschl +9 more
TL;DR: Using PAR-CLIP, global RNA targets for all human FET proteins and two ALS-causing human FUS mutants were defined and FET members showed similar binding profiles, whereas F US mutants showed a drastically altered binding pattern, consistent with changes in subcellular localization.
Journal ArticleDOI
MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells
Gero Doose,Andrea Haake,Stephan H. Bernhart,Cristina López,Sujitha Duggimpudi,Franziska Wojciech,Anke K. Bergmann,Arndt Borkhardt,Birgit Burkhardt,Alexander Claviez,Lora Dimitrova,Siegfried Haas,Jessica I. Hoell,Michael Hummel,Dennis Karsch,Wolfram Klapper,Karsten Kleo,Helene Kretzmer,Markus Kreuz,Ralf Küppers,Chris Lawerenz,Dido Lenze,Markus Loeffler,Luisa Mantovani-Löffler,Peter Möller,German Ott,Julia Richter,Marius Rohde,Philip Rosenstiel,Andreas Rosenwald,Markus Schilhabel,Markus Schneider,Ingrid Scholz,Stephan Stilgenbauer,Hendrik G. Stunnenberg,Monika Szczepanowski,Lorenz Trümper,Marc A. Weniger,Steve Hoffmann,Reiner Siebert,Ingram Iaccarino +40 more
TL;DR: It is suggested that MINCR is a newly identified player in the MYC transcriptional network able to control the expression of cell cycle genes and may open new therapeutic windows in the fight against malignant lymphoma and, possibly, all cancers that rely on MYC expression.
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Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.
Prashant V. Shinde,Haifeng C. Xu,Sathish Kumar Maney,Andreas Kloetgen,Sukumar Namineni,Yuan Zhuang,Nadine Honke,Namir Shaabani,Nicolás Bellora,Mareike Doerrenberg,Mirko Trilling,Vitaly I. Pozdeev,Nico van Rooijen,Stefanie Scheu,Klaus Pfeffer,Paul R. Crocker,Masato Tanaka,Sujitha Duggimpudi,Percy A. Knolle,Mathias Heikenwalder,Mathias Heikenwalder,Jürgen Ruland,Tak W. Mak,Dirk Brenner,Aleksandra A. Pandyra,Jessica I. Hoell,Arndt Borkhardt,Dieter Häussinger,Karl S. Lang,Philipp A. Lang +29 more
TL;DR: After vesicular stomatitis virus infection, phagocytes produce tumor necrosis factor (TNF), which signals via TNFR1, and promote enforced virus replication in CD169+ macrophages, indicating that TNF mediates the maintenance ofCD169+ cells and innate and adaptive immune activation during VSV infection.
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Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling.
Sujitha Duggimpudi,Andreas Kloetgen,Sathish Kumar Maney,Philipp C. Münch,Kebria Hezaveh,Hamed Shaykhalishahi,Wolfgang Hoyer,Alice C. McHardy,Philipp A. Lang,Arndt Borkhardt,Jessica I. Hoell +10 more
TL;DR: Multiple MSI2-regulated mRNAs are identified and evidence that MSI2 controls IL6ST activity that control oncogenic signaling networks is provided, which may help inform strategies for unraveling the role of MSI2 in leukemia to pave the way for the development of targeted therapies.
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The Cell Cycle Regulator CCDC6 Is a Key Target of RNA-Binding Protein EWS
TL;DR: Evidence is provided for a novel functional link through which wild-type EWS operates in a target-dependant manner in Ewing sarcoma and CCDC6, a known cell cycle regulator protein, is demonstrated as a novel target regulated by EWS.