H
Haifeng C. Xu
Researcher at University of Düsseldorf
Publications - 37
Citations - 2091
Haifeng C. Xu is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Lymphocytic choriomeningitis & CD8. The author has an hindex of 16, co-authored 32 publications receiving 1699 citations. Previous affiliations of Haifeng C. Xu include University of Duisburg-Essen & Princess Margaret Cancer Centre.
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Journal ArticleDOI
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.
Tuoqi Wu,Yun Ji,E. Ashley Moseman,Haifeng C. Xu,Monica Manglani,Martha Kirby,Stacie M. Anderson,Robin Handon,Elizabeth Kenyon,Abdel G. Elkahloun,Weiwei Wu,Philipp A. Lang,Luca Gattinoni,Dorian B. McGavern,Pamela L. Schwartzberg +14 more
TL;DR: Insight is provided into the requirements for persistence of T cell immune responses in the face of exhaustion and mechanisms by which effective T cell–mediated immunity may be enhanced during chronic infections and cancer are suggested.
Journal ArticleDOI
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.
David R. McIlwain,Philipp A. Lang,Philipp A. Lang,Thorsten Maretzky,Koichi Hamada,Kazuhito Ohishi,Sathish Kumar Maney,Thorsten Berger,Aditya Murthy,Gordon S. Duncan,Haifeng C. Xu,Haifeng C. Xu,Karl S. Lang,Dieter Häussinger,Andrew Wakeham,Annick Itie-Youten,Rama Khokha,Pamela S. Ohashi,Pamela S. Ohashi,Carl P. Blobel,Carl P. Blobel,Tak W. Mak,Tak W. Mak +22 more
TL;DR: iRhom2 is identified as a regulator of innate immunity that may be an important target for modulating sepsis and pathogen defense and was critical for TACE maturation and trafficking to the cell surface in hematopoietic cells.
Journal ArticleDOI
Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity
Philipp A. Lang,Karl S. Lang,Haifeng C. Xu,Melanie Grusdat,Ian A. Parish,Mike Recher,Alisha R. Elford,Salim Dhanji,Namir Shaabani,Charles W. Tran,Dilan Dissanayake,Ramtin Rahbar,Magar Ghazarian,Anne Brüstle,Jason P. Fine,Peter Chen,Casey T. Weaver,Christoph S.N. Klose,Andreas Diefenbach,Dieter Häussinger,James R. Carlyle,Susan M. Kaech,Tak W. Mak,Pamela S. Ohashi +23 more
TL;DR: It is shown that NKG2D triggered regulatory NK cell functions, which were mediated by perforin, and limited T-cell responses, which led to rapid virus control and prevented chronic infection in lymphocytic choriomeningitis virus clone 13- and reduced viral load in DOCILE- infected animals.
Journal ArticleDOI
Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.
Haifeng C. Xu,Haifeng C. Xu,Melanie Grusdat,Aleksandra A. Pandyra,Robin Polz,Jun Huang,Piyush Sharma,René Deenen,Karl Köhrer,Ramtin Rahbar,Andreas Diefenbach,Kathrin Gibbert,Max Löhning,Max Löhning,Lena Höcker,Zoe Waibler,Dieter Häussinger,Tak W. Mak,Pamela S. Ohashi,Karl S. Lang,Philipp A. Lang +20 more
TL;DR: Using the murine lymphocytic choriomeningitis virus model system, it is shown that IFN-I signaling on T cells prevented their rapid elimination in vivo, and was identified as a key player regulating the protection of T cells against regulatory NK cell function.
Journal ArticleDOI
NK cells regulating T cell responses: mechanisms and outcome.
TL;DR: Emerging principles of how this regulation of natural killer cells influences the overall outcome of adaptive immunity in infection and disease are outlined.