Jessica I. Hoell

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.

TL;DR: Using PAR-CLIP, global RNA targets for all human FET proteins and two ALS-causing human FUS mutants were defined and FET members showed similar binding profiles, whereas F US mutants showed a drastically altered binding pattern, consistent with changes in subcellular localization.

TL;DR: Interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation are unraveled.

TL;DR: It is suggested that MINCR is a newly identified player in the MYC transcriptional network able to control the expression of cell cycle genes and may open new therapeutic windows in the fight against malignant lymphoma and, possibly, all cancers that rely on MYC expression.