S
Suman Acharya
Researcher at Yeungnam University
Publications - 17
Citations - 211
Suman Acharya is an academic researcher from Yeungnam University. The author has contributed to research in topics: T cell & Medicine. The author has an hindex of 5, co-authored 13 publications receiving 95 citations. Previous affiliations of Suman Acharya include Tribhuvan University & Kathmandu.
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Journal ArticleDOI
Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
Maheshwor Timilshina,Zhiwei You,Sonja M. Lacher,Suman Acharya,Liyuan Jiang,Youra Kang,Jung-Ae Kim,Hyeun Wook Chang,Keuk-Jun Kim,Byoungduck Park,Jae-Hyoung Song,Hyun-Jeong Ko,Yun-Yong Park,Min-Jung Ma,Mahesh Raj Nepal,Tae Cheon Jeong,Yeonseok Chung,Ari Waisman,Jae-Hoon Chang +18 more
TL;DR: LKB1 is a key regulator of lipid metabolism in Treg cells, involved in optimal programming of suppressive activity, immune homeostasis, and tolerance and found to regulate intracellular cholesterolHomeostasis and to promote the mevalonate pathway.
Journal ArticleDOI
Reprogramming the T cell response to cancer by simultaneous, nanoparticle-mediated PD-L1 inhibition and immunogenic cell death
Cao Dai Phung,Hanh Thuy Nguyen,Ju Yeon Choi,Thanh Tung Pham,Suman Acharya,Maheshwor Timilshina,Jae-Hoon Chang,Ju Hyun Kim,Jee-Heon Jeong,Sae-Kwang Ku,Han-Gon Choi,Chul Soon Yong,Jong Oh Kim +12 more
TL;DR: The results suggest that simultaneous PD-L1 inhibition via microRNAs and the induction of an immunogenic tumor microenvironment via low-dose cytotoxic drugs may improve cancer therapy efficacy.
Journal ArticleDOI
Amelioration of Experimental autoimmune encephalomyelitis and DSS induced colitis by NTG-A-009 through the inhibition of Th1 and Th17 cells differentiation
Suman Acharya,Maheshwor Timilshina,Liyuan Jiang,Sabita Neupane,Dong-Young Choi,Sang Won Park,Sang Yeul Lee,Byeong-Seon Jeong,Jung-Ae Kim,Tae-gyu Nam,Jae-Hoon Chang +10 more
TL;DR: It is demonstrated that NTG-A-009 ameliorated inflammation through the inhibition of Th1 and Th17 cells generation making it a potential therapeutic candidate for the treatment of inflammatory diseases.
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AMPK promotes antitumor immunity by downregulating PD-1 in regulatory T cells via the HMGCR/p38 signaling pathway
Ram Hari Pokhrel,Suman Acharya,Jae-Hee Ahn,Ye Gu,Mahesh Pandit,Jong Oh Kim,Yun-Yong Park,Ben Kang,Hyun-Jeong Ko,Jae-Hoon Chang +9 more
TL;DR: In this paper, the role of AMP activation in suppressing programmed cell death 1 (PD-1) expression and mechanistic investigation was investigated in the context of the HMGCR/p38 MAPK/GSK3β signaling pathway.
Journal ArticleDOI
Mevalonate promotes differentiation of regulatory T cells.
TL;DR: The results suggest that mevalonate enhanced Treg differentiation and ameliorated DSS colitis, indicating its potential for treatment of inflammatory diseases.