T
Tatyana A. Prokhorova
Researcher at University of Southern Denmark
Publications - 21
Citations - 1839
Tatyana A. Prokhorova is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Embryonic stem cell & Medicine. The author has an hindex of 10, co-authored 15 publications receiving 1697 citations. Previous affiliations of Tatyana A. Prokhorova include University of Dundee & Harvard University.
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Journal ArticleDOI
System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation
Kristoffer T.G. Rigbolt,Tatyana A. Prokhorova,Vyacheslav Akimov,Jeanette Henningsen,Jeanette Henningsen,Pia Thermann Johansen,Irina Kratchmarova,Moustapha Kassem,Moustapha Kassem,Matthias Mann,Jesper V. Olsen,Blagoy Blagoev +11 more
TL;DR: Cellular events underlying the pluripotency of human embryonic stem cells (hESCs) are elucidated and a core hESC phosphoproteome of sites with similar robust changes in response to the two distinct treatments is identified.
Journal ArticleDOI
MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts.
Melissa C. Edwards,Antonin V. Tutter,Christin Cvetic,Catherine H. Gilbert,Tatyana A. Prokhorova,Johannes C. Walter +5 more
TL;DR: The data suggest that in Xenopus egg extracts, origins of replication contain multiple, distributed, initiation-competent MCM2–7 complexes.
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The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly.
Vladimir Joukov,Aaron C. Groen,Tatyana A. Prokhorova,Ruth Gerson,Erinn White,Alison Rodriguez,Johannes C. Walter,David M. Livingston +7 more
TL;DR: It is shown that, in both mammalian cells and Xenopus egg extracts, BRCA1/BARD1 is required for mitotic spindle-pole assembly and for accumulation of TPX2, a major spindle organizer and Ran target, on spindle poles.
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Teratoma Formation by Human Embryonic Stem Cells Is Site Dependent and Enhanced by the Presence of Matrigel
Tatyana A. Prokhorova,Linda Harkness,Ulrik Frandsen,Nicholas Ditzel,Henrik Daa Schrøder,Jorge S. Burns,Moustapha Kassem +6 more
TL;DR: Subcutaneous implantation of hESCs in presence of Matrigel appears to be the most efficient, reproducible, and the easiest approach for teratoma formation by hESC lines.
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Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45.
James A. Wohlschlegel,Suman Kumar Dhar,Tatyana A. Prokhorova,Anindya Dutta,Johannes C. Walter +4 more
TL;DR: It is reported that Xenopus Mcm10 (XMcm10) is not required for origin binding of XMcm2-7, and the chromatin binding at the onset of DNA replication requires chromatin-bound XMc m10, and it is independent of Cdk2 and Cdc7.