S
Sumanprava Giri
Researcher at University of Illinois at Urbana–Champaign
Publications - 12
Citations - 1090
Sumanprava Giri is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Origin recognition complex & Chromatin. The author has an hindex of 10, co-authored 12 publications receiving 894 citations. Previous affiliations of Sumanprava Giri include Harvard University.
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Journal ArticleDOI
Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.
Vidisha Tripathi,Zhen Shen,Arindam Chakraborty,Sumanprava Giri,Susan M. Freier,Xiaolin Wu,Yongqing Zhang,Myriam Gorospe,Supriya G. Prasanth,Ashish Lal,Kannanganattu V. Prasanth +10 more
TL;DR: It is demonstrated that MALAT1 levels are regulated during normal cell cycle progression, and mechanistic insights on the role of MALat1 in regulating cellular proliferation are provided.
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Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
TL;DR: In addition to sensing DNA damage and replication stress, RPA is a sensor of R loops and a regulator of RNaseH1, extending the versatile role of RPA in suppression of genomic instability.
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Dynamic Association of ORCA with Prereplicative Complex Components Regulates DNA Replication Initiation
Zhen Shen,Arindam Chakraborty,Ankur Jain,Sumanprava Giri,Taekjip Ha,Kannanganattu V. Prasanth,Supriya G. Prasanth +6 more
TL;DR: It is found that ORCA is required for the G1-to-S-phase transition in human cells and the dynamic association of ORCA with pre-RC components modulates the assembly of its interacting partners on chromatin and facilitates DNA replication initiation.
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The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin
Sumanprava Giri,Vasudha Aggarwal,Julien Pontis,Zhen Shen,Arindam Chakraborty,A. Ali Khan,Craig A. Mizzen,Kannanganattu V. Prasanth,Slimane Ait-Si-Ali,Taekjip Ha,Supriya G. Prasanth +10 more
TL;DR: It is demonstrated that ORCA acts as a scaffold for the establishment of H3K9 KMT complex and its association and activity at specific chromatin sites is crucial for the organization of heterochromatin structure.
Journal ArticleDOI
BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase
A. Ali Khan,Sumanprava Giri,Yating Wang,Arindam Chakraborty,Archit K. Ghosh,Aparna Anantharaman,Vasudha Aggarwal,Kizhakke Mattada Sathyan,Taekjip Ha,Kannanganattu V. Prasanth,Supriya G. Prasanth +10 more
TL;DR: It is demonstrated in mammalian cells that BANP, E5R, and Nac1 (BEN) domain 3 (BEND3), a quadruple BEN domain-containing protein, localizes in nucleoli and binds to ribosomal RNA gene promoters to help repress rRNA genes.