S
Sunny Z. Wu
Researcher at Garvan Institute of Medical Research
Publications - 32
Citations - 1307
Sunny Z. Wu is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Stromal cell & Breast cancer. The author has an hindex of 7, co-authored 28 publications receiving 526 citations. Previous affiliations of Sunny Z. Wu include University of New South Wales & University of Sydney.
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Journal ArticleDOI
A single-cell and spatially resolved atlas of human breast cancers.
Sunny Z. Wu,Sunny Z. Wu,Ghamdan Al-Eryani,Ghamdan Al-Eryani,Daniel L. Roden,Daniel L. Roden,Simon Junankar,Simon Junankar,Kate Harvey,Alma Andersson,Aatish Thennavan,Chenfei Wang,James R. Torpy,James R. Torpy,Nenad Bartonicek,Nenad Bartonicek,Taopeng Wang,Taopeng Wang,Ludvig Larsson,Dominik C. Kaczorowski,Neil I. Weisenfeld,Cedric Uytingco,Jennifer Chew,Zachary Bent,Chia-Ling Chan,Vikkitharan Gnanasambandapillai,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Laurence Gluch,Mun N. Hui,Jane Beith,Andrew Parker,Andrew Parker,Elizabeth Robbins,Davendra Segara,Caroline Cooper,Caroline Cooper,Cindy Mak,Belinda Chan,Sanjay Warrier,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Ewan K.A. Millar,Ewan K.A. Millar,Ewan K.A. Millar,Joseph E. Powell,Joseph E. Powell,Stephen R. Williams,X. Shirley Liu,Sandra A O'Toole,Elgene Lim,Elgene Lim,Elgene Lim,Joakim Lundeberg,Charles M. Perou,Alexander Swarbrick,Alexander Swarbrick +57 more
TL;DR: In this paper, a single-cell and spatially resolved transcriptomics analysis of human breast cancers is presented, which reveals recurrent neoplastic cell heterogeneity and heterotypic interactions play central roles in disease progression.
Journal ArticleDOI
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
Aurélie Cazet,Aurélie Cazet,Mun N. Hui,Benjamin Elsworth,Sunny Z. Wu,Sunny Z. Wu,Daniel L. Roden,Daniel L. Roden,Chia Ling Chan,Joanna N. Skhinas,Raphael Collot,Jessica Yang,Kate Harvey,M. Zahied Johan,M. Zahied Johan,Caroline Cooper,Radhika Nair,David Herrmann,David Herrmann,Andrea McFarland,Niantao Deng,Niantao Deng,Manuel Ruiz-Borrego,Federico Rojo,Jose Manuel Trigo,Susana Bezares,Rosalía Caballero,Elgene Lim,Paul Timpson,Paul Timpson,Sandra A O'Toole,Sandra A O'Toole,D. Neil Watkins,Thomas R. Cox,Thomas R. Cox,Michael S. Samuel,Michael S. Samuel,Miguel Martin,Alexander Swarbrick,Alexander Swarbrick +39 more
TL;DR: It is demonstrated that cancer cell-derived Hedgehog ligand triggers stromal remodeling that in turn induces a cancer-stem-cell like, drug-resistant phenotype of nearby cancer cells while treatment with smoothened inhibitors reverses these phenotypes.
Journal ArticleDOI
Stromal cell diversity associated with immune evasion in human triple-negative breast cancer.
Sunny Z. Wu,Sunny Z. Wu,Daniel L. Roden,Daniel L. Roden,Chenfei Wang,Holly Holliday,Holly Holliday,Kate Harvey,Aurélie Cazet,Aurélie Cazet,Kendelle J. Murphy,Kendelle J. Murphy,Brooke A. Pereira,Brooke A. Pereira,Ghamdan Al-Eryani,Ghamdan Al-Eryani,Nenad Bartonicek,Nenad Bartonicek,Rui Hou,James R. Torpy,James R. Torpy,Simon Junankar,Simon Junankar,Chia Ling Chan,Chuan En Lam,Mun N. Hui,Laurence Gluch,Jane Beith,Andrew Parker,Elizabeth Robbins,Davendra Segara,Cindy Mak,Caroline Cooper,Caroline Cooper,Sanjay Warrier,Alistair R. R. Forrest,Joseph E. Powell,Joseph E. Powell,Sandra A O'Toole,Sandra A O'Toole,Thomas R. Cox,Thomas R. Cox,Paul Timpson,Paul Timpson,Elgene Lim,Elgene Lim,Elgene Lim,X. Shirley Liu,Alexander Swarbrick,Alexander Swarbrick +49 more
TL;DR: Investigation of gene signatures from inflammatory‐CAFs and differentiated‐PVL cells in independent TNBC patient cohorts revealed strong associations with cytotoxic T‐cell dysfunction and exclusion, respectively, presenting promising candidates for new therapeutic strategies in the treatment of TNBCs.
Journal ArticleDOI
Cognition in People With End-Stage Kidney Disease Treated With Hemodialysis: A Systematic Review and Meta-analysis.
Emma O'Lone,Emma O'Lone,Michael H. Connors,Philip Masson,Philip Masson,Philip Masson,Sunny Z. Wu,Patrick J. Kelly,David Gillespie,Daniel Parker,William Whiteley,Giovanni F.M. Strippoli,Giovanni F.M. Strippoli,Suetonia C. Palmer,Jonathan C. Craig,Jonathan C. Craig,Angela C Webster,Angela C Webster +17 more
TL;DR: People treated with hemodialysis have impaired cognitive function compared to the general population, particularly in the domains of orientation and attention and executive function.
Journal ArticleDOI
Cognition in chronic kidney disease: a systematic review and meta-analysis
Israel Berger,Sunny Z. Wu,Philip Masson,Patrick J. Kelly,Fiona Duthie,William Whiteley,Daniel Parker,David Gillespie,Angela C Webster +8 more
TL;DR: The cognitive impact of CKD is likely to diminish patients’ capacity to engage with healthcare decisions and an individual’s cognitive trajectory may deviate from average.