Sunoh Kim

TL;DR: It is demonstrated that the activation of 5-HT6R activated the extracellular signal-regulated kinase1/2 via an Fyn-dependent pathway, suggesting that Fyn may play an important role in 5- HT6R- mediated signaling pathways in the central nervous system.

TL;DR: Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr97, Gly98, Phe101, and Arg267 of Gpr92 are responsible for the interaction of G PR92 with FPP and NAG.

TL;DR: Examination of the direct modulation of ginseng on the activation of glutamate, especially NMDA, receptors in cultured hippocampal neurons suggests that the inhibition of NMDA receptors by gINSeng, in particular by ginsenoside Rg3, could be one of the mechanisms for ginsENG-mediated neuroprotective actions.

TL;DR: The results are the first to show that stimulation of NPCs may lead to either proliferation or neuronal differentiation, depending on the level of NMDA receptor activation, and suggest that neurogenesis in the developing brain is likely to be both directly and indirectly regulated by complex interactions between Ca2+ influx and excitation-releasable cytokines, even at mild levels of excitation.

TL;DR: It is found that the N terminus of the rat Cav1.3 α1 subunit interacts with a partial N-terminal amino acid sequence of ryanodine receptor type 2 (RyR2) and that RyR2 mRNA itself is increased by long term treatment of high-K via activation of L-type Ca2+ channels.