R
Robert K. Naviaux
Researcher at University of California, San Diego
Publications - 138
Citations - 8468
Robert K. Naviaux is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrial disease. The author has an hindex of 45, co-authored 131 publications receiving 7533 citations. Previous affiliations of Robert K. Naviaux include Scripps Health & Center for Excellence in Education.
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The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses.
TL;DR: The pCL system permits the investigator to control the level of gene expression in target cells over a 100-fold range, while maintaining uniformly high titers of virus from transiently transfected producer cells.
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Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease
Kumar Sharma,Bethany Karl,Anna V. Mathew,Jon A. Gangoiti,Christina L. Wassel,Rintaro Saito,Minya Pu,Shoba Sharma,Young Hyun You,Lin Wang,Maggie Diamond-Stanic,Maja T. Lindenmeyer,Carol Forsblom,Wei Wu,Joachim H. Ix,Trey Ideker,Jeffrey B. Kopp,Sanjay K. Nigam,Clemens D. Cohen,Per-Henrik Groop,Per-Henrik Groop,Bruce A. Barshop,Loki Natarajan,William L. Nyhan,Robert K. Naviaux +24 more
TL;DR: It is concluded that urine metabolomics is a reliable source for biomarkers of diabetic complications, and the data suggest that renal organic ion transport and mitochondrial function are dysregulated in diabetic kidney disease.
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POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion
Robert K. Naviaux,Khue Vu Nguyen +1 more
TL;DR: In two unrelated pedigrees of Alpers' syndrome, each affected child was found to carry a homozygous mutation in exon 17 of the POLG locus that led to a Glu873Stop mutation just upstream of the polymerase domain of the protein.
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AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
Laura L. Dugan,Young Hyun You,Young Hyun You,Sameh S. Ali,Maggie Diamond-Stanic,Maggie Diamond-Stanic,Satoshi Miyamoto,Satoshi Miyamoto,Anne-Emilie Decleves,Anne-Emilie Decleves,Aleksander Andreyev,Tammy Quach,Tammy Quach,San Ly,San Ly,Grigory Shekhtman,William Nguyen,Andre Chepetan,Thuy Le,Lin Wang,Ming Xu,Kacie P. Paik,Agnes B. Fogo,Benoit Viollet,Anne N. Murphy,Frank C. Brosius,Robert K. Naviaux,Kumar Sharma,Kumar Sharma +28 more
TL;DR: It is demonstrated that diabetic kidneys have reduced superoxide and mitochondrial biogenesis and activation of AMPK enhances superoxide production and mitochondrial function while reducing disease activity.
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Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo.
TL;DR: Sustained expression of factor IX protein for over 6 months without any apparent adverse effect on the recipient mice is reported.