L
Lin Wang
Researcher at University of California, San Diego
Publications - 104
Citations - 5465
Lin Wang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Optic nerve & Optic disk. The author has an hindex of 39, co-authored 99 publications receiving 4751 citations. Previous affiliations of Lin Wang include Scripps Research Institute & Legacy Health.
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Journal ArticleDOI
Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease
Kumar Sharma,Bethany Karl,Anna V. Mathew,Jon A. Gangoiti,Christina L. Wassel,Rintaro Saito,Minya Pu,Shoba Sharma,Young Hyun You,Lin Wang,Maggie Diamond-Stanic,Maja T. Lindenmeyer,Carol Forsblom,Wei Wu,Joachim H. Ix,Trey Ideker,Jeffrey B. Kopp,Sanjay K. Nigam,Clemens D. Cohen,Per-Henrik Groop,Per-Henrik Groop,Bruce A. Barshop,Loki Natarajan,William L. Nyhan,Robert K. Naviaux +24 more
TL;DR: It is concluded that urine metabolomics is a reliable source for biomarkers of diabetic complications, and the data suggest that renal organic ion transport and mitochondrial function are dysregulated in diabetic kidney disease.
Journal ArticleDOI
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
Laura L. Dugan,Young Hyun You,Young Hyun You,Sameh S. Ali,Maggie Diamond-Stanic,Maggie Diamond-Stanic,Satoshi Miyamoto,Satoshi Miyamoto,Anne-Emilie Decleves,Anne-Emilie Decleves,Aleksander Andreyev,Tammy Quach,Tammy Quach,San Ly,San Ly,Grigory Shekhtman,William Nguyen,Andre Chepetan,Thuy Le,Lin Wang,Ming Xu,Kacie P. Paik,Agnes B. Fogo,Benoit Viollet,Anne N. Murphy,Frank C. Brosius,Robert K. Naviaux,Kumar Sharma,Kumar Sharma +28 more
TL;DR: It is demonstrated that diabetic kidneys have reduced superoxide and mitochondrial biogenesis and activation of AMPK enhances superoxide production and mitochondrial function while reducing disease activity.
Journal ArticleDOI
Metabolic features of chronic fatigue syndrome
Robert K. Naviaux,Jane C. Naviaux,Kefeng Li,A. Taylor Bright,William A. Alaynick,Lin Wang,Asha Baxter,Neil Nathan,Wayne F. Anderson,Eric M Gordon +9 more
TL;DR: Targeted, broad-spectrum metabolomics of plasma showed that chronic fatigue syndrome is a highly concerted hypometabolic response to environmental stress that traces to mitochondria and was similar to the classically studied developmental state of dauer, opening a fresh path for the rational development of new therapeutics.
Journal ArticleDOI
Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
Jane C. Naviaux,Lin Wang,Kefeng Li,A. Taylor Bright,William A. Alaynick,Kenneth R Williams,Kenneth R Williams,Susan B. Powell,Susan B. Powell,Robert K. Naviaux +9 more
TL;DR: The data show that antipurinergic therapy improves the multisystem, ASD-like features of both the environmental MIA, and the genetic Fragile X models.
Journal Article
Immunohistologic Evidence for Retinal Glial Cell Changes in Human Glaucoma
TL;DR: The activation of glial cells in the glaucomatous retina was characterized in changes of intensity of GFAP immunoreactivity and morphology around the larger blood vessels, compared with age-matched normal retinas.