Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area
Greta E Weiss,Peter D. Crompton,Shanping Li,Laura A. Walsh,Susan Moir,Boubacar Traore,Kassoum Kayentao,Aissata Ongoiba,Ogobara K. Doumbo,Susan K. Pierce +9 more
Reads0
Chats0
TLDR
Evidence is provided that a phenotypically similar atypical MBC population is significantly expanded in Pf-exposed Malian adults and children as young as 2 years of age as compared with healthy U.S. adult controls.Abstract:
Epidemiological observations in malaria endemic areas have long suggested a deficiency in the generation and maintenance of B cell memory to Plasmodium falciparum (Pf) in individuals chronically reinfected with the parasite. Recently, a functionally and phenotypically distinct population of FCRL4(+) hyporesponsive memory B cells (MBCs) was reported to be expanded in HIV-infected individuals with high viral loads. In this study, we provide evidence that a phenotypically similar atypical MBC population is significantly expanded in Pf-exposed Malian adults and children as young as 2 years of age as compared with healthy U.S. adult controls. The number of these atypical MBCs was higher in children with chronic asymptomatic Pf infections compared with uninfected children, suggesting that the chronic presence of the parasite may drive expansion of these distinct MBCs. This is the first description of an atypical MBC phenotype associated with malaria. Understanding the origin and function of these MBCs could be important in informing the design of malaria vaccines.read more
Citations
More filters
Journal ArticleDOI
T cell exhaustion
TL;DR: Advances in the molecular delineation of T cell exhaustion are clarifying the underlying causes of this state of differentiation and also suggest promising therapeutic opportunities.
Journal ArticleDOI
Comprehensive mapping of immune perturbations associated with severe COVID-19.
Leticia Kuri-Cervantes,M. Betina Pampena,Wenzhao Meng,Aaron M. Rosenfeld,Caroline A. G. Ittner,Ariel R. Weisman,R.S. Agyekum,Divij Mathew,Amy E. Baxter,Laura A. Vella,Laura A. Vella,Oliva Kuthuru,Sokratis A. Apostolidis,Sokratis A. Apostolidis,Luanne Bershaw,Jeanette Dougherty,Allison R. Greenplate,Ajinkya Pattekar,Ajinkya Pattekar,Justin Kim,Nicholas Han,Sigrid Gouma,Madison E. Weirick,Claudia P. Arevalo,Marcus J. Bolton,Eileen C. Goodwin,Elizabeth M. Anderson,Scott E. Hensley,Tiffanie K. Jones,Nilam S. Mangalmurti,Eline T. Luning Prak,E. John Wherry,Nuala J. Meyer,Michael R. Betts +33 more
TL;DR: The neutrophil to lymphocyte ratio is found to be a prognostic biomarker of disease severity and organ failure and broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
Journal ArticleDOI
Memory B cells.
TL;DR: This Review discusses the underlying mechanisms that are required for rapid and effective recall antibody responses in memory B cells, focusing on the contributions of other types of cells, such as memory T follicular helper cells.
Journal ArticleDOI
Burkitt's lymphoma
Elizabeth Molyneux,Rosemary Rochford,Beverly E. Griffin,Robert U. Newton,Graham Jackson,Geetha R Menon,Christine J. Harrison,Trijn Israels,Simon Bailey +8 more
TL;DR: Adjuvant monoclonal antibody therapy with rituximab shows promise for improved outcomes and reduced toxic effects in the future.
Journal ArticleDOI
Reference values for B cell subpopulations from infancy to adulthood
TL;DR: In this article, the authors characterized developmental changes in peripheral B cell populations from infancy to adulthood in order to define age-dependent reference values using a flow cytometric approach and analyzed the frequencies as well as the absolute counts of naive, switched and non-switched memory B cells.
References
More filters
Journal ArticleDOI
The global distribution of clinical episodes of Plasmodium falciparum malaria
TL;DR: It is estimated that there were 515 (range 300–660) million episodes of clinical P. falciparum malaria in 2002, up to 50% higher than those reported by the World Health Organization and 200% higher for areas outside Africa, reflecting the WHO's reliance upon passive national reporting for these countries.
Journal ArticleDOI
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Cheryl L. Day,Daniel Kaufmann,Photini Kiepiela,Julia A. Brown,Eshia Moodley,Sharon Reddy,Elizabeth W Mackey,Joseph D. Miller,Alasdair Leslie,Chantal DePierres,Zenele Mncube,Jaikumar Duraiswamy,Baogong Zhu,Quentin Eichbaum,Marcus Altfeld,E. John Wherry,Hoosen M. Coovadia,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder,Paul Klenerman,Rafi Ahmed,Gordon J. Freeman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker +25 more
TL;DR: The data indicate that the immunoregulatory PD-1/PD-L1 pathway is operative during a persistent viral infection in humans, and define a reversible defect in HIV-specific T-cell function.
Journal ArticleDOI
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
E. John Wherry,Sang Jun Ha,Susan M. Kaech,W. Nicholas Haining,Surojit Sarkar,Vandana Kalia,Shruti Subramaniam,Joseph N. Blattman,Daniel L. Barber,Rafi Ahmed +9 more
TL;DR: T cell exhaustion was progressive, and gene-expression profiling indicated that T cell exhaustion and anergy were distinct processes, which provides a framework for designing rational immunotherapies during chronic infections.
Journal ArticleDOI
Upregulation of PD-1 expression on HIV-specific CD8 + T cells leads to reversible immune dysfunction
Lydie Trautmann,Loury Janbazian,Loury Janbazian,Nicolas Chomont,Elias A. Said,Sylvain Gimmig,Benoit Bessette,Mohamed Rachid Boulassel,Eric Delwart,Homero Sepulveda,Robert Balderas,Jean-Pierre Routy,Jean-Pierre Routy,Elias K. Haddad,Elias K. Haddad,Rafick Pierre Sekaly,Rafick Pierre Sekaly +16 more
TL;DR: Blocking PD-1 engagement to its ligand (PD-L1) enhanced the capacity of HIV-specific CD8+ T cells to survive and proliferate and led to an increased production of cytokines and cytotoxic molecules in response to cognate antigen.