S
Suzanne Hoppins
Researcher at University of Washington
Publications - 26
Citations - 2941
Suzanne Hoppins is an academic researcher from University of Washington. The author has contributed to research in topics: mitochondrial fusion & MFN2. The author has an hindex of 14, co-authored 24 publications receiving 2630 citations. Previous affiliations of Suzanne Hoppins include University of Alberta & University of California, Davis.
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Journal ArticleDOI
The Machines that Divide and Fuse Mitochondria
TL;DR: This review focuses on what is currently known about the novel molecular machines that divide and fuse mitochondria, which are derived from eubacteria.
Journal ArticleDOI
A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.
Suzanne Hoppins,Sean R. Collins,Ann Cassidy-Stone,Eric Hummel,Rachel M. DeVay,Laura L. Lackner,Benedikt Westermann,Maya Schuldiner,Jonathan S. Weissman,Jodi Nunnari +9 more
TL;DR: Statement MITO-MAP, a high-density genetic interaction map in budding yeast, identifies a mitochondrial inner membrane–associated complex that promotes normal mitochondrial membrane organization and morphology.
Journal ArticleDOI
Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion
Rachel M. DeVay,Lenin Domínguez-Ramírez,Laura L. Lackner,Suzanne Hoppins,Henning Stahlberg,Jodi Nunnari +5 more
TL;DR: The soluble and membrane-anchored isoforms of Mgm1 are only active when they work together (in trans) and the two types of isoforms are distinguished by their racemates.
Journal ArticleDOI
Uniform nomenclature for the mitochondrial contact site and cristae organizing system
Nikolaus Pfanner,Martin van der Laan,Paolo Amati,Roderick A. Capaldi,Amy A. Caudy,Agnieszka Chacinska,Manjula Darshi,Markus Deckers,Suzanne Hoppins,Tateo Icho,Stefan Jakobs,Stefan Jakobs,Jianguo Ji,Vera Kozjak-Pavlovic,Chris Meisinger,Paul R. Odgren,Sang Ki Park,Peter Rehling,Peter Rehling,Andreas S. Reichert,M. Saeed Sheikh,Susan S. Taylor,Nobuo Tsuchida,Alexander M. van der Bliek,Ida J. van der Klei,Jonathan S. Weissman,Benedikt Westermann,Jiping Zha,Walter Neupert,Jodi Nunnari +29 more
TL;DR: The mitochondrial inner membrane contains a large protein complex that functions in inner membrane organization and formation of membrane contact sites and it is proposed to unify the nomenclature and term the complex “mitochondrial contact site and cristae organizing system” and its subunits Mic10 to Mic60.
Journal ArticleDOI
The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes
Suzanne Hoppins,Frank Edlich,Megan M. Cleland,Soojay Banerjee,J. Michael McCaffery,Richard J. Youle,Jodi Nunnari +6 more
TL;DR: It is demonstrated that heterotypicMFN1-MFN2 trans complexes possess greater efficacy in fusion as compared to homotypic MFN1 or MFN2 complexes, and it is shown that the soluble form of the proapoptotic Bcl2 protein, Bax, positively regulates mitochondrial fusion exclusively through homotyped MFN 2 trans complexes.