S
Svend Kjaer
Researcher at Francis Crick Institute
Publications - 77
Citations - 4737
Svend Kjaer is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Coronavirus. The author has an hindex of 26, co-authored 70 publications receiving 3574 citations. Previous affiliations of Svend Kjaer include Karolinska Institutet & London Research Institute.
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Journal ArticleDOI
The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition.
Joanna R. Kelly,Silvia Martini,Nicola Brownlow,Nicola Brownlow,Dhira Joshi,Stefania Federico,Shirin Jamshidi,Svend Kjaer,Nicola Lockwood,Khondaker M. Rahman,Franca Fraternali,Peter J. Parker,Peter J. Parker,Tanya N. Soliman,Tanya N. Soliman +14 more
TL;DR: It is shown that Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε, which protects from chromosome non-disjunction by delaying anaphase entry and promoting TopoIIα-dependent resolution.
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Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer
Annika Fendler,Scott Shepherd,Lewis Au,Mary Y. Wu,Ruth Harvey,Katalin A. Wilkinson,Andreas M. Schmitt,Z Tippu,B. Shum,Sheima Farag,Aljosja Rogiers,Eleanor Carlyle,Kim Edmonds,L. Del Rosario,Karla Lingard,Mary Mangwende,L. Holt,Hamid Ahmod,Justine Korteweg,Tara Foley,Taja Barber,Andrea Emslie-Henry,Niamh Caulfield-Lynch,Fiona Byrne,Daqi Deng,Svend Kjaer,Ok-Ryul Song,Christophe J. Queval,Caitlin Kavanagh,Emma C. Wall,Edward J. Carr,Simon Caidan,Mike Gavrielides,James I. MacRae,Gavin Kelly,Kema Peat,Denise Kelly,Aida Murra,Kayleigh Kelly,M.S. O'Flaherty,Robyn Shea,Gail Gardner,Darren Murray,Sanjay Popat,Nadia Yousaf,Shaman Jhanji,Kate Tatham,David Cunningham,Nicholas van As,Kate Young,Andrew Furness,Lisa Pickering,Rupert Beale,Charles Swanton,Sonia Gandhi,Steven J. Gamblin,David L.V. Bauer,George Kassiotis,Michael Howell,Emma Nicholson,Susan Walker,Robert J. Wilkinson,James Larkin,Samra Turajlic +63 more
TL;DR: Fendler et al. as discussed by the authors measured neutralizing antibody titers (NAbTs) using a live virus microneutralization assay against wild-type (WT), Delta, and Omicron BA.
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5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
William Mahy,Nicky J. Willis,Yuguang Zhao,Hannah Woodward,Fredrik Svensson,Fredrik Svensson,James Sipthorp,James Sipthorp,L. Vecchia,Reinis R. Ruza,James Hillier,Svend Kjaer,S. Frew,Amy Monaghan,Magda Bictash,Patricia C. Salinas,Paul Whiting,Jean-Paul Vincent,E. Yvonne Jones,Paul V. Fish,Paul V. Fish +20 more
TL;DR: Significant progress was made in developing fragment hit 7 into lead 23dd (>600-fold increase in activity), making it suitable as a new chemical tool for exploring the role of Notum-mediated regulation of Wnt signaling.
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A small molecule inhibitor of HER3: a proof-of-concept study.
Audrey Colomba,Martina Fitzek,Roger George,Gregory Weitsman,Selene K. Roberts,Laura C. Zanetti-Domingues,Michael Hirsch,Daniel J. Rolfe,Shahid Mehmood,Andrew Madin,Jeroen Claus,Svend Kjaer,Ambrosius P. Snijders,Tony Ng,Marisa L. Martin-Fernandez,David M. Smith,Peter J. Parker,Peter J. Parker +17 more
TL;DR: A multiplex, medium-throughput thermal shift assay screening strategy to assess over 100 000 compounds and identify selective small molecule inhibitors that would trap HER3 in a conformation which is unfavourable for the formation of an active HER2–HER3 heterodimer is developed.
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O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern
Edgar Gonzalez-Rodriguez,Mia I. Zol-Hanlon,Ganka Bineva-Todd,and Emanuela Marchesi,Mark Skehel,Keira E. Mahoney,Chloe Roustan,Annabel Borg,Lucia Di Vagno,Svend Kjaer,A.G. Wrobel,D.J. Benton,Philipp Nawrath,Sabine L. Flitsch,Dhira Joshi,Andrés Manuel González-Ramírez,Katalin A. Wilkinson,Robert J. Wilkinson,Ramon Hurtado-Guerrero,Stacy A. Malaker,Benjamin Schumann +20 more
TL;DR: O-glycosylation is established as a major determinant of spike maturation and a likely driving force for the emergence of common mutations in variants such as omicron, delta and alpha in SARS-CoV-2.