S
Svend Kjaer
Researcher at Francis Crick Institute
Publications - 77
Citations - 4737
Svend Kjaer is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Glial cell line-derived neurotrophic factor & Coronavirus. The author has an hindex of 26, co-authored 70 publications receiving 3574 citations. Previous affiliations of Svend Kjaer include Karolinska Institutet & London Research Institute.
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Journal ArticleDOI
A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome
Aline C. Simon,Jin C. Zhou,Rajika L. Perera,Rajika L. Perera,Frederick van Deursen,Cecile Evrin,Marina E. Ivanova,Marina E. Ivanova,Mairi L. Kilkenny,Ludovic Renault,Svend Kjaer,Dijana Matak-Vinkovic,Karim Labib,Alessandro Costa,Luca Pellegrini +14 more
TL;DR: The findings indicate that Ctf4 can couple two molecules of Pol α to one CMG helicase within the replisome, providing a new model for lagging-strand synthesis in eukaryotes that resembles the emerging model for the simpler replisomes of Escherichia coli.
Journal ArticleDOI
Molecular Modeling of the Extracellular Domain of the RET Receptor Tyrosine Kinase Reveals Multiple Cadherin-like Domains and a Calcium-binding Site
TL;DR: The models of the cadherin-like domains of human RET represent valuable tools with which to guide future site-directed mutagenesis studies aimed at identifying residues involved in ligand binding and receptor activation.
Journal ArticleDOI
Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
Julian Stingele,Roberto Bellelli,Ferdinand Alte,Graeme Hewitt,Grzegorz Sarek,Sarah L. Maslen,Susan E. Tsutakawa,Annabel Borg,Svend Kjaer,John A. Tainer,John A. Tainer,J. Mark Skehel,Michael Groll,Simon J. Boulton +13 more
TL;DR: The metalloprotease SPRTN is identified as the DPC protease acting in metazoans and provided a molecular explanation on how SPRTN deficiency causes the premature aging and cancer predisposition disorder Ruijs-Aalfs syndrome.
Journal ArticleDOI
Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
Jasmine V. Abella,Chiara Galloni,Julien Pernier,David J. Barry,Svend Kjaer,Marie-France Carlier,Michael Way +6 more
TL;DR: It is found that Arp2/3 complexes containing AR PC1B and ARPC5L are significantly better at promoting actin assembly than those with ARPC1A and AR PC5, both in cells and in vitro.
Posted ContentDOI
Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Chris Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Philip A. Walker,Svend Kjaer,Andrew Riddell,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis +31 more
TL;DR: The presence of pre-existing humoral immunity in uninfected and unexposed humans to the new coronavirus is demonstrated and identified as SARS-CoV-2 S-reactive antibodies, which were readily detectable by a sensitive flow cytometry-based method in SARS/COVID-19-uninfected individuals and were particularly prevalent in children and adolescents.