S
Swati Choudhary
Researcher at Copenhagen University Hospital
Publications - 12
Citations - 351
Swati Choudhary is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Circulating tumor cell & Cancer cell. The author has an hindex of 5, co-authored 12 publications receiving 228 citations. Previous affiliations of Swati Choudhary include Indian Institute of Technology Madras.
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Journal ArticleDOI
An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.
Alejandro Gomez Toledo,Jessica Pihl,Charlotte B Spliid,Charlotte B Spliid,Andrea Persson,Jonas Nilsson,Marina Ayres Pereira,Tobias Gustavsson,Swati Choudhary,Htoo Zarni Oo,Peter C. Black,Mads Daugaard,Jeffrey D. Esko,Göran Larson,Ali Salanti,Thomas Mandel Clausen,Thomas Mandel Clausen +16 more
TL;DR: It is demonstrated how affinity purification in combination with glycoproteomics analysis can facilitate the characterization of CSPGs with distinct CS epitopes, including novel core proteins.
Journal ArticleDOI
Targeting c-kit receptor in neuroblastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxins
Swati Choudhary,Alessa Pardo,Reinhard Rosinke,Janendra K. Batra,Stefan Barth,Stefan Barth,Rama Shanker Verma +6 more
TL;DR: This study demonstrates the role of stem cell factor (SCF)-based toxin conjugates for targeting WT-KIT-overexpressing malignancies such as NBs and CRCs and proves that these novel targeting agents have promising potential as KIT receptor tyrosine kinase targeting system.
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Optimization of rVAR2-Based Isolation of Cancer Cells in Blood for Building a Robust Assay for Clinical Detection of Circulating Tumor Cells.
Nicolai T Sand,Tobias B Petersen,Sara R. Bang-Christensen,Theresa D Ahrens,Caroline Løppke,Amalie M. Jørgensen,Tobias Gustavsson,Swati Choudhary,Thor G. Theander,Ali Salanti,Mette Ø. Agerbæk +10 more
TL;DR: This study describes a technical approach for optimizing the coupling of rVAR2 to magnetic beads and the development of a CTC isolation platform targeting a range of different cancer cell lines and concludes that an indirect capture approach is most effective for rVar2-based cancer cell retrieval.
Journal ArticleDOI
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility.
Charlotte B Spliid,Charlotte B Spliid,Alejandro Gomez Toledo,Alejandro Gomez Toledo,Patience Sanderson,Yang Mao,Francesco Gatto,Tobias Gustavsson,Swati Choudhary,Ana L. Saldanha,Rasmus Peuliche Vogelsang,Ismail Gögenur,Thor G. Theander,Franklin E. Leach rd,I. Jonathan Amster,Jeffrey D. Esko,Ali Salanti,Thomas Mandel Clausen +17 more
TL;DR: In this paper, the exact structure of chondroitin sulfate (ofCS) and what determines the selective tropism of VAR2CSA remains poorly understood, however, it has been shown that both placenta and tumors contain significantly more chidon sulfate moieties than other tissues.
Journal ArticleDOI
SNAP-Tag Technology: A Promising Tool for Ex Vivo Immunophenotyping.
TL;DR: First evidence that SNAP-tag could be used for ex vivo detection of enriched biological markers is reported, in comparison with anti-c-kit antibody for peripheral blood samples from leukemia patients and colorectal tissue specimens.