Sylvain Le Jeune

TL;DR: In transgenic SAD mice, infusion of heme-laden MPs triggered rapid vasoocclusions in kidneys and compromised microvascular dilation ex vivo, and may provide new targets for the therapeutic preservation of vascular function in SCD.

TL;DR: It is demonstrated that intravascular hemolysis triggers complement activation in vivo, encouraging further studies on its role in SCD nephropathy and heme inhibition using hemopexin may provide a novel therapeutic opportunity to limit complementactivation in hemolytic diseases.

TL;DR: Inorganic antigens may contribute to paediatric sarcoidosis as discussed by the authors, especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products.

TL;DR: Four cases in which HU was taken during all pregnancy collected in the ESCORT-HU study (European Sickle Cell Disease COhoRT - HydroxyUrea), a multicentric, prospective, non-interventional European study which collected long-term safety information on HU when used in current practice are presented.

TL;DR: The ESCORT-HU (European Sickle Cell Disease Cohort - Hydroxyurea) as discussed by the authors is a multicenter prospective non-interventional study implemented in Europe to collect more information about the safety profile and morbidity-mortality in SCD patients treated with HU.