S
Sylvie Job
Publications - 23
Citations - 1022
Sylvie Job is an academic researcher. The author has contributed to research in topics: Clear cell renal cell carcinoma & Sunitinib. The author has an hindex of 15, co-authored 23 publications receiving 730 citations.
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Journal ArticleDOI
Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting
Benoit Beuselinck,Sylvie Job,Etienne Becht,Alexandra Karadimou,Alexandra Karadimou,Virginie Verkarre,Virginie Verkarre,Gabrielle Couchy,Gabrielle Couchy,Nicolas A. Giraldo,Nathalie Rioux-Leclercq,Vincent Molinié,Mathilde Sibony,Mathilde Sibony,Reza Elaidi,Corinne Teghom,Jean Jacques Patard,Arnaud Mejean,Wolf H. Fridman,Catherine Sautès-Fridman,Aurélien de Reyniès,Stéphane Oudard,Jessica Zucman-Rossi +22 more
TL;DR: In this paper, the authors performed global transcriptome analysis on 53 primary resected ccRCC tumors from patients who developed metastatic disease and were treated with first-line sunitinib.
Journal ArticleDOI
Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma
Sylvie Job,Delphine Rapoud,Delphine Rapoud,Alexandre Dos Santos,Alexandre Dos Santos,Patrick Gonzalez,Patrick Gonzalez,Christophe Desterke,G. Pascal,G. Pascal,Nabila Elarouci,Mira Ayadi,René Adam,René Adam,Daniel Azoulay,Daniel Azoulay,Denis Castaing,Denis Castaing,Eric Vibert,Eric Vibert,Daniel Cherqui,Daniel Cherqui,Didier Samuel,Didier Samuel,Antonio Sa Cuhna,Antonio Sa Cuhna,Agnès Marchio,Pascal Pineau,Catherine Guettier,Catherine Guettier,Aurélien de Reyniès,Jamila Faivre,Jamila Faivre +32 more
TL;DR: The heterogeneous tumor stroma composition is investigated and a TME‐based classification of ICC tumors that detects potentially targetable ICC subtypes is built.
Journal ArticleDOI
CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis.
Alain C. Jung,Sébastien Guihard,Sylvie Krugell,Sonia Ledrappier,Alexandra Brochot,Véronique Dalstein,Sylvie Job,Aurélien de Reyniès,Georges Noël,Bohdan Wasylyk,Christine Clavel,Joseph Abecassis +11 more
TL;DR: The results suggest that an increased cytotoxic T‐cell‐based antitumor immune response is involved in improved prognosis of patients with HPV‐positive tumors.
Journal ArticleDOI
Telomerase Activation and ATRX Mutations Are Independent Risk Factors for Metastatic Pheochromocytoma and Paraganglioma.
Sylvie Job,Irena Draskovic,Irena Draskovic,Nelly Burnichon,Nelly Burnichon,Alexandre Buffet,Alexandre Buffet,Jérôme Cros,Charles Lépine,Annabelle Venisse,Estelle Robidel,Estelle Robidel,Virginie Verkarre,Tchao Meatchi,Mathilde Sibony,Mathilde Sibony,Laurence Amar,Laurence Amar,Jérôme Bertherat,Aurélien de Reyniès,Arturo Londoño-Vallejo,Arturo Londoño-Vallejo,Judith Favier,Judith Favier,Luis Jaime Castro-Vega,Luis Jaime Castro-Vega,Anne-Paule Gimenez-Roqueplo +26 more
TL;DR: Assessment of telomerase activation and ATRX mutations could be used to identify metastatic PPGLs, particularly in tumors at high risk of progression.
Journal ArticleDOI
Transcriptional profiling of pure fibrolamellar hepatocellular carcinoma reveals an endocrine signature
Gabriel G. Malouf,Sylvie Job,Valérie Paradis,Monique Fabre,Laurence Brugières,Pierre Saintigny,Laure Vescovo,Jacques Belghiti,Sophie Branchereau,Sandrine Faivre,Aurélien de Reyniès,Eric Raymond +11 more
TL;DR: In this paper, the authors identify two distinct molecular subgroups of fibrolamellar hepatocellular carcinoma (FLC) with different outcomes: pure FLC and mixed FLC (m-FLC), differing in clinical presentation and course.