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Etienne Becht
Researcher at Fred Hutchinson Cancer Research Center
Publications - 86
Citations - 11960
Etienne Becht is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: CD8 & Immune system. The author has an hindex of 35, co-authored 84 publications receiving 6932 citations. Previous affiliations of Etienne Becht include Paris Descartes University & Agency for Science, Technology and Research.
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Journal ArticleDOI
Dimensionality reduction for visualizing single-cell data using UMAP.
Etienne Becht,Leland McInnes,John Healy,Charles-Antoine Dutertre,Immanuel Kwok,Lai Guan Ng,Florent Ginhoux,Evan W. Newell,Evan W. Newell +8 more
TL;DR: Comparing the performance of UMAP with five other tools, it is found that UMAP provides the fastest run times, highest reproducibility and the most meaningful organization of cell clusters.
Journal ArticleDOI
Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression
Etienne Becht,Nicolas A. Giraldo,Nicolas A. Giraldo,Nicolas A. Giraldo,Laetitia Lacroix,Laetitia Lacroix,Laetitia Lacroix,Bénédicte Buttard,Bénédicte Buttard,Bénédicte Buttard,Nabila Elarouci,Florent Petitprez,Janick Selves,Pierre Laurent-Puig,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Wolf H. Fridman,Wolf H. Fridman,Wolf H. Fridman,Aurélien de Reyniès +20 more
TL;DR: The Microenvironment Cell Populations-counter method is introduced, which allows the robust quantification of the absolute abundance of eight immune and two stromal cell populations in heterogeneous tissues from transcriptomic data and demonstrates that MCP-counter overcomes several limitations or weaknesses of previously proposed computational approaches.
Journal ArticleDOI
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Yannick Simoni,Etienne Becht,Michael G. Fehlings,Chiew Yee Loh,Si-Lin Koo,Karen Wei Weng Teng,Joe Poh Sheng Yeong,Joe Poh Sheng Yeong,Rahul Nahar,Tong Zhang,Hassen Kared,Kaibo Duan,Nicholas Ang,Michael Poidinger,Yin Yeng Lee,Anis Larbi,Alexis Jiaying Khng,Emile Tan,Cherylin Fu,Ronnie Mathew,Melissa Ching Ching Teo,Wan-Teck Lim,Chee Keong Toh,Boon-Hean Ong,Tina Koh,Axel M. Hillmer,Angela Takano,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Eng Huat Tan,Weiwei Zhai,Daniel Shao-Weng Tan,Daniel Shao-Weng Tan,Iain Beehuat Tan,Iain Beehuat Tan,Iain Beehuat Tan,Evan W. Newell +37 more
TL;DR: It is shown that human lung and colorectal cancer CD8+ TILs can not only be specific for tumour antigens, but also recognize a wide range of epitopes unrelated to cancer (such as those from Epstein–Barr virus, human cytomegalovirus or influenza virus).
Journal ArticleDOI
Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer
Claire Germain,Sacha Gnjatic,Fella Tamzalit,Samantha Knockaert,Romain Remark,Jeremy Goc,Alice Lepelley,Etienne Becht,Sandrine Katsahian,Geoffray Bizouard,Pierre Validire,Diane Damotte,Marco Alifano,Pierre Magdeleinat,Isabelle Cremer,Jean-Luc Teillaud,Wolf H. Fridman,Catherine Sautès-Fridman,Marie-Caroline Dieu-Nosjean +18 more
TL;DR: B-cell density represents a new prognostic biomarker for NSCLC patient survival, and makes the link between TLS and a protective B cell-mediated immunity.
Journal ArticleDOI
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells.
Jeremy Goc,Claire Germain,Thi Kim Duy Vo-Bourgais,Audrey Lupo,Christophe Klein,Samantha Knockaert,Luc de Chaisemartin,Hanane Ouakrim,Etienne Becht,Marco Alifano,Pierre Validire,Romain Remark,Scott A. Hammond,Isabelle Cremer,Diane Damotte,Wolf H. Fridman,Catherine Sautès-Fridman,Marie-Caroline Dieu-Nosjean +17 more
TL;DR: These results show how tumors infiltrated by TLS-associated mature DC generate a specific immune contexture characterized by a strong Th1 and cytotoxic orientation that confers the lowest risk of death.