P
Pascal Pineau
Researcher at Pasteur Institute
Publications - 141
Citations - 5825
Pascal Pineau is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Hepatocellular carcinoma & Hepatitis B virus. The author has an hindex of 33, co-authored 130 publications receiving 5270 citations. Previous affiliations of Pascal Pineau include French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
miR-221 overexpression contributes to liver tumorigenesis
Pascal Pineau,Stefano Volinia,Katherine McJunkin,Agnès Marchio,Carlo Battiston,Benoit Terris,Vincenzo Mazzaferro,Scott W. Lowe,Carlo M. Croce,Anne Dejean +9 more
TL;DR: It is shown, using a mouse model of liver cancer, that miR-221 overexpression stimulates growth of tumorigenic murine hepatic progenitor cells, and DNA damage-inducible transcript 4 (DDIT4), a modulator of mTOR pathway, is identified as a bona fide target of miR -221.
Journal ArticleDOI
p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
Taewan Kim,Angelo Veronese,Flavia Pichiorri,Tae Jin Lee,Young-Jun Jeon,Stefano Volinia,Pascal Pineau,Agnès Marchio,Jeff Palatini,Sung Suk Suh,Hansjuerg Alder,Chang Gong Liu,Anne Dejean,Carlo M. Croce +13 more
TL;DR: By transactivating expression of miRNAs that repress expression of the ZEB1 and ZEB2 transcription factors, p53 inhibits the epithelial–mesenchymal transition.
Journal ArticleDOI
Reprogramming of miRNA networks in cancer and leukemia
Stefano Volinia,Marco Galasso,Stefan Costinean,Luca Tagliavini,Giacomo Gamberoni,Alessandra Drusco,Jlenia Marchesini,Nicoletta Mascellani,Maria Elena Sana,Ramzey Abu Jarour,Caroline Desponts,Michael A. Teitell,Raffaele Baffa,Rami I. Aqeilan,Marilena V. Iorio,Cristian Taccioli,Ramiro Garzon,Gianpiero Di Leva,Muller Fabbri,Marco Catozzi,Maurizio Previati,Stefan Ambs,Tiziana Palumbo,Michela Garofalo,Angelo Veronese,Arianna Bottoni,Pierluigi Gasparini,Curtis C. Harris,Rosa Visone,Yuri Pekarsky,Albert de la Chapelle,Mark Bloomston,Mary Dillhoff,Laura Z. Rassenti,Thomas J. Kipps,Kay Huebner,Flavia Pichiorri,Dido Lenze,Stefano Cairo,Marie Annick Buendia,Pascal Pineau,Anne Dejean,Nicola Zanesi,Simona Rossi,George A. Calin,Chang Gong Liu,Jeff Palatini,Massimo Negrini,Andrea Vecchione,Anne L. Rosenberg,Carlo M. Croce +50 more
TL;DR: In this paper, the authors studied miRNA profiles in 4419 human samples (3312 neoplastic, 1107 nonmalignant), corresponding to 50 normal tissues and 51 cancer types.
Journal ArticleDOI
Comprehensive allelotyping of human hepatocellular carcinoma.
TL;DR: This first report of an extensive allelotypic analysis of HCC should help in identifying new genes whose loss of function contributes to the development of liver cancer.
Journal ArticleDOI
Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization.
Agnès Marchio,Mounira Meddeb,Pascal Pineau,Gisèle Danglot,Pierre Tiollais,Alain Bernheim,Anne Dejean +6 more
TL;DR: This study represents the first analysis of primary liver cancers by CGH, and it confirms the presence of previously known chromosomal aberrations in HCC and highlights new quantitative abnormalities and sequence amplifications.