T
T. G. Nygaard
Researcher at Columbia University
Publications - 44
Citations - 3740
T. G. Nygaard is an academic researcher from Columbia University. The author has contributed to research in topics: Dystonia & Parkinsonism. The author has an hindex of 34, co-authored 44 publications receiving 3677 citations. Previous affiliations of T. G. Nygaard include Harvard University & NewYork–Presbyterian Hospital.
Papers
More filters
Journal Article
Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22
TL;DR: It is suggested that the DDPAC locus should be screened as a candidate locus in family studies of conditions with behavioral abnormalities and neurological degeneration.
Journal ArticleDOI
Mitochondrial neurogastrointestinal encephalomyopathy: An autosomal recessive disorder due to thymidine phosphorylase mutations
Ichizo Nishino,Antonella Spinazzola,A. Papadimitriou,S Hammans,I Steiner,Cecil D. Hahn,Anne M. Connolly,Alain Verloes,J Guimarães,Ivan Maillard,H Hamano,M.A. Donati,Carol E. Semrad,James A. Russell,Antonio L. Andreu,Georgios M. Hadjigeorgiou,Tuan Vu,Saba Tadesse,T. G. Nygaard,Ikuya Nonaka,I Hirano,Eduardo Bonilla,Lewis P. Rowland,Salvatore DiMauro,Michio Hirano +24 more
TL;DR: Mitochondrial neurogastrointestinal encephalomyopathy is an autosomal recessive disorder defined clinically by severe gastrointestinal dysmotility; cachexia; ptosis, ophthalmoparesis, or both; peripheral neuropathy; leukoencephalopathy; and mitochondrial abnormalities.
Journal ArticleDOI
Clinical characteristics of a family with chromosome 17‐linked disinhibition‐dementia‐ parkinsonism‐amyotrophy complex
Timothy Lynch,Mary Sano,Karen Marder,Karen L. Bell,Norman L. Foster,R. F. Defending,Anders A. F. Sima,Catherine Keohane,T. G. Nygaard,Stanley Fahn,Richard Mayeux,Lewis P. Rowland,Kirk C. Wilhelmsen +12 more
TL;DR: This disorder is called the "disinhibition-dementia-parkinsonism-amyotrophy complex" (DDPAC), based on the clinical syndrome found in this family and linkage to chromosome 17.
Journal ArticleDOI
Dopa-responsive dystonia: long-term treatment response and prognosis.
TL;DR: Observations on the treatment of 66 patients with presumed dopa-responsive dystonia indicate that some patients with clinical syndromes suggestive of DRD may not have an excellent prognosis on long-term levodopa treatment and may represent misclassified cases of childhood-onset parkinsonism.
Journal ArticleDOI
Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families.
L. Almasy,Susan B. Bressman,D. Raymond,Patricia L. Kramer,Paul Greene,Gary A. Heiman,Blair Ford,J. Yount,Deborah de Leon,Sylvain Chouinard,R. Saunders-Pullman,Mitchell F. Brin,R. P. Kapoor,Alison C. Jones,H. Shen,Stanley Fahn,Neil Risch,T. G. Nygaard +17 more
TL;DR: A locus (DYT6) associated with prominent cranial–cervical ITD in two large Mennonite families to chromosome 8 is mapped, suggesting a shared mutation from the recent past.