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Gary A. Heiman

Researcher at Rutgers University

Publications -  95
Citations -  5949

Gary A. Heiman is an academic researcher from Rutgers University. The author has contributed to research in topics: Tourette syndrome & Dystonia. The author has an hindex of 42, co-authored 89 publications receiving 5005 citations. Previous affiliations of Gary A. Heiman include Columbia University & Semel Institute for Neuroscience and Human Behavior.

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil Lee, +606 more
- 12 Dec 2019 - 
TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.
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Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

Lea K. Davis, +130 more
- 24 Oct 2013 - 
TL;DR: The results indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.
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L-histidine decarboxylase and Tourette's syndrome.

A. Gulhan Ercan-Sencicek, +27 more
- 20 May 2010 - 
TL;DR: An analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis points to a role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics.
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Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

Dongmei Yu, +81 more
- 01 Mar 2019 - 
TL;DR: Modulation of gene expression through noncoding variants, particularly within cortico-striatal circuits, is implicated as a fundamental mechanism in Tourette's syndrome pathogenesis, supporting the unification of Tourette’s syndrome and other tic disorders in future diagnostic schemata.
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Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism

Thomas V. Fernandez, +23 more
- 01 Mar 2012 - 
TL;DR: Further evidence is identified supporting recent findings regarding the involvement of histaminergic and gamma-aminobutyric acidergic mechanisms in the etiology of TS and an overlap of rare CNVs in TS and autism spectrum disorders is identified.