C
Catherine Keohane
Researcher at University College Cork
Publications - 95
Citations - 4596
Catherine Keohane is an academic researcher from University College Cork. The author has contributed to research in topics: Biopsy & Neuropathology. The author has an hindex of 25, co-authored 95 publications receiving 3684 citations. Previous affiliations of Catherine Keohane include National University of Ireland & Beaumont Hospital.
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Journal ArticleDOI
DNA methylation-based classification of central nervous system tumours
David Capper,David Capper,David Capper,David T.W. Jones,Martin Sill,Volker Hovestadt,Daniel Schrimpf,Daniel Schrimpf,Dominik Sturm,Dominik Sturm,Christian Koelsche,Christian Koelsche,Felix Sahm,Felix Sahm,Lukas Chavez,David E. Reuss,David E. Reuss,Annekathrin Kratz,Annekathrin Kratz,Annika K. Wefers,Annika K. Wefers,Kristin Huang,Kristin Huang,Kristian W. Pajtler,Kristian W. Pajtler,Leonille Schweizer,Leonille Schweizer,Damian Stichel,Damian Stichel,Adriana Olar,Nils W. Engel,Nils W. Engel,Kerstin Lindenberg,Patrick N. Harter,Patrick N. Harter,Anne K. Braczynski,Anne K. Braczynski,Karl H. Plate,Karl H. Plate,Hildegard Dohmen,Boyan K. Garvalov,Roland Coras,Annett Hölsken,Ekkehard Hewer,Melanie Bewerunge-Hudler,Matthias Schick,Roger Fischer,Rudi Beschorner,Jens Schittenhelm,Ori Staszewski,Khalida Wani,Pascale Varlet,Mélanie Pagès,Petra Temming,Dietmar R. Lohmann,Florian Selt,Florian Selt,Hendrik Witt,Hendrik Witt,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Eleonora Aronica,Felice Giangaspero,Elisabeth J. Rushing,Wolfram Scheurlen,Christoph Geisenberger,Christoph Geisenberger,Fausto J. Rodriguez,Albert J. Becker,Matthias Preusser,Christine Haberler,Rolf Bjerkvig,Jane Cryan,Michael A. Farrell,Martina Deckert,Jürgen Hench,Stephan Frank,Jonathan Serrano,Kasthuri Kannan,Aristotelis Tsirigos,Wolfgang Brück,Silvia Hofer,Stefanie Brehmer,Marcel Seiz-Rosenhagen,Daniel Hänggi,Volkmar Hans,Stephanie Rozsnoki,Jordan R. Hansford,Patricia Kohlhof,Bjarne Winther Kristensen,Matt Lechner,Beatriz Lopes,Christian Mawrin,Ralf Ketter,Andreas E. Kulozik,Ziad Khatib,Frank L. Heppner,Arend Koch,Anne Jouvet,Catherine Keohane,Helmut Mühleisen,Wolf Mueller,Ute Pohl,Marco Prinz,Axel Benner,Marc Zapatka,Nicholas G. Gottardo,Nicholas G. Gottardo,Pablo Hernáiz Driever,Christof M. Kramm,Hermann L. Müller,Stefan Rutkowski,Katja von Hoff,Michael C. Frühwald,Astrid Gnekow,Gudrun Fleischhack,Stephan Tippelt,Gabriele Calaminus,Camelia-Maria Monoranu,Arie Perry,Chris Jones,Thomas S. Jacques,Bernhard Radlwimmer,Marco Gessi,Torsten Pietsch,Johannes Schramm,Gabriele Schackert,Manfred Westphal,Guido Reifenberger,Guido Reifenberger,Pieter Wesseling,Pieter Wesseling,Michael Weller,Vincent Peter Collins,Ingmar Blümcke,Martin Bendszus,Jürgen Debus,Annie Huang,Nada Jabado,Paul A. Northcott,Werner Paulus,Amar Gajjar,Giles W. Robinson,Michael D. Taylor,Zane Jaunmuktane,Marina Ryzhova,Michael Platten,Andreas Unterberg,Wolfgang Wick,Matthias A. Karajannis,Michel Mittelbronn,Till Acker,Christian Hartmann,Kenneth Aldape,Ulrich Schüller,Ulrich Schüller,Rolf Buslei,Peter Lichter,Marcel Kool,Christel Herold-Mende,David W. Ellison,Martin Hasselblatt,Matija Snuderl,Sebastian Brandner,Andrey Korshunov,Andrey Korshunov,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister +171 more
TL;DR: This work presents a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and shows that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods.
Journal ArticleDOI
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm,Dominik Sturm,Brent A. Orr,Umut H. Toprak,Volker Hovestadt,David T.W. Jones,David Capper,David Capper,Martin Sill,Ivo Buchhalter,Paul A. Northcott,Irina Leis,Marina Ryzhova,Christian Koelsche,Christian Koelsche,Elke Pfaff,Elke Pfaff,Sariah Allen,Gnanaprakash Balasubramanian,Barbara C. Worst,Barbara C. Worst,Kristian W. Pajtler,Sebastian Brabetz,Pascal Johann,Pascal Johann,Felix Sahm,Felix Sahm,Jüri Reimand,Jüri Reimand,Alan Mackay,Diana Carvalho,Marc Remke,Joanna J. Phillips,Arie Perry,Cynthia Cowdrey,Rachid Drissi,Maryam Fouladi,Felice Giangaspero,Maria Łastowska,Wiesława Grajkowska,Wolfram Scheurlen,Torsten Pietsch,Christian Hagel,Johannes Gojo,Daniela Lötsch,Walter Berger,Irene Slavc,Christine Haberler,Anne Jouvet,Stefan Holm,Silvia Hofer,Marco Prinz,Catherine Keohane,Iris Fried,Christian Mawrin,David Scheie,Bret C. Mobley,Matthew Schniederjan,Mariarita Santi,Anna Maria Buccoliero,Sonika Dahiya,Christof M. Kramm,André O. von Bueren,Katja von Hoff,Stefan Rutkowski,Christel Herold-Mende,Michael C. Frühwald,Till Milde,Till Milde,Martin Hasselblatt,Pieter Wesseling,Pieter Wesseling,Jochen Rößler,Ulrich Schüller,Martin Ebinger,Jens Schittenhelm,Stephan Frank,Rainer Grobholz,Istvan Vajtai,Volkmar Hans,Reinhard Schneppenheim,Karel Zitterbart,V. Peter Collins,Eleonora Aronica,Pascale Varlet,Stéphanie Puget,Christelle Dufour,Jacques Grill,Dominique Figarella-Branger,Marietta Wolter,Martin U. Schuhmann,Tarek Shalaby,Michael A. Grotzer,Timothy E. Van Meter,Camelia M. Monoranu,Jörg Felsberg,Guido Reifenberger,Matija Snuderl,Lynn Ann Forrester,Jan Koster,Rogier Versteeg,Richard Volckmann,Peter van Sluis,Stephan Wolf,Tom Mikkelsen,Amar Gajjar,Kenneth Aldape,Andrew S. Moore,Michael D. Taylor,Chris Jones,Nada Jabado,Matthias A. Karajannis,Roland Eils,Matthias Schlesner,Peter Lichter,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister,David W. Ellison,Andrey Korshunov,Andrey Korshunov,Marcel Kool +122 more
TL;DR: It is demonstrated that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors.
Journal ArticleDOI
Clinical characteristics of a family with chromosome 17‐linked disinhibition‐dementia‐ parkinsonism‐amyotrophy complex
Timothy Lynch,Mary Sano,Karen Marder,Karen L. Bell,Norman L. Foster,R. F. Defending,Anders A. F. Sima,Catherine Keohane,T. G. Nygaard,Stanley Fahn,Richard Mayeux,Lewis P. Rowland,Kirk C. Wilhelmsen +12 more
TL;DR: This disorder is called the "disinhibition-dementia-parkinsonism-amyotrophy complex" (DDPAC), based on the clinical syndrome found in this family and linkage to chromosome 17.
Journal ArticleDOI
Neuronal apoptosis in HIV infection in adults.
Homa Adle-Biassette,Y. Levy,M. Colornbel,F. Poron,S. Natchev,Catherine Keohane,Françoise Gray +6 more
TL;DR: Neuronal apoptosis was more severe in atrophic brains, and did not directly correlate with productive HIV infection, suggesting an indirect mechanism of neuronal damage is most likely.
Journal Article
Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS.
A. V. Vallat,U. De Girolami,J. He,Abner M. Mhashilkar,Wayne A. Marasco,B Shi,Françoise Gray,Jeanne E. Bell,Catherine Keohane,Thomas W. Smith,Dana Gabuzda +10 more
TL;DR: Findings suggest that CCR5-positive mononuclear cells, macrophages, and microglia contribute to disease progression in the central nervous system of children and adults with AIDS by serving as targets for virus replication.