T
Tadashi Umekage
Researcher at University of Tokyo
Publications - 62
Citations - 1971
Tadashi Umekage is an academic researcher from University of Tokyo. The author has contributed to research in topics: Panic disorder & Single-nucleotide polymorphism. The author has an hindex of 25, co-authored 62 publications receiving 1796 citations.
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Association of the oxytocin receptor ( OXTR ) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population
Xiaoxi Liu,Yoshiya Kawamura,Takafumi Shimada,Takeshi Otowa,Shinko Koishi,Toshiro Sugiyama,Hisami Nishida,Ohiko Hashimoto,Ryoichi Nakagami,Mamoru Tochigi,Tadashi Umekage,Yukiko Kano,Taku Miyagawa,Nobumasa Kato,Katsushi Tokunaga,Tsukasa Sasaki +15 more
TL;DR: This study might support that OXTR has a significant role in conferring the risk of ASD in the Japanese population by analyzing 11 single-nucleotide polymorphisms (SNPs) using both family-based association test (FBAT) and population-based case–control test.
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Genome-wide association study of panic disorder in the Japanese population.
Takeshi Otowa,Eiji Yoshida,Nagisa Sugaya,Shin Yasuda,Yukika Nishimura,Ken Inoue,Mamoru Tochigi,Tadashi Umekage,Taku Miyagawa,Nao Nishida,Katsushi Tokunaga,Hisashi Tanii,Tsukasa Sasaki,Hisanobu Kaiya,Yuji Okazaki +14 more
TL;DR: Seven SNPs were significantly associated with PD, which were located in or adjacent to genes including PKP1, PLEKHG1, TMEM16B, CALCOCO1, SDK2 and CLU (or APO-J).
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Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia
Morihiro Shimabukuro,Tsukasa Sasaki,Akira Imamura,Takahiro Tsujita,Chiaki Fuke,Tadashi Umekage,Mamoru Tochigi,Kennichi Hiramatsu,Tetsuji Miyazaki,Takaya Oda,Jun Sugimoto,Yoshihiro Jinno,Yuji Okazaki +12 more
TL;DR: It is established that there is significant sex-dependent difference in the mC content of human peripheral leukocyte DNA, and the possibility that alterations in DNA methylation state are present in patients with schizophrenia is raised.
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Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes.
Mamoru Tochigi,Takeshi Otowa,Hiroyuki Hibino,Chieko Kato,Toshiyuki Otani,Tadashi Umekage,Takeshi Utsumi,Nobumasa Kato,Tsukasa Sasaki +8 more
TL;DR: The results may provide evidence for the association between metabolic change of catecholamines and personality traits, which may be due to the additive effect of the three genes.
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Genome-wide Association Study of Autism Spectrum Disorder in the East Asian Populations.
Xiaoxi Liu,Takafumi Shimada,Takeshi Otowa,Yu-Yu Wu,Yoshiya Kawamura,Mamoru Tochigi,Yasuhide Iwata,Tadashi Umekage,Tomoko Toyota,Motoko Maekawa,Yoshimi Iwayama,Katsuaki Suzuki,Chihiro Kakiuchi,Hitoshi Kuwabara,Yukiko Kano,Hisami Nishida,Toshiro Sugiyama,Nobumasa Kato,Chia-Hsiang Chen,Chia-Hsiang Chen,Norio Mori,Kazuo Yamada,Takeo Yoshikawa,Kiyoto Kasai,Katsushi Tokunaga,Tsukasa Sasaki,Susan Shur-Fen Gau +26 more
TL;DR: The results provide independent support to known ASD candidate genes and highlight a number of novel genes warranted to be further investigated in a larger sample set in an effort to improve the understanding of the genetic basis of ASD.