T
Tsukasa Sasaki
Researcher at University of Tokyo
Publications - 250
Citations - 8702
Tsukasa Sasaki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 46, co-authored 247 publications receiving 7676 citations. Previous affiliations of Tsukasa Sasaki include Teikyo University & Tokyo Metropolitan Matsuzawa Hospital.
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Journal ArticleDOI
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study
Philip C Haycock,Stephen Burgess,Aayah Nounu,Jie Zheng,G N Okoli,Jack Bowden,Kaitlin H Wade,Nicholas J. Timpson,David M. Evans,Peter Willeit,Abraham Aviv,Tom R. Gaunt,Gibran Hemani,Massimo Mangino,Hayley P Ellis,Kathreena M Kurian,Karen A. Pooley,Rosalind A. Eeles,Jeffrey E. Lee,Shenying Fang,Wei V. Chen,Matthew Law,Lisa Bowdler,Mark M. Iles,Qiong Yang,Bradford B. Worrall,Hugh S. Markus,Rayjean J. Hung,Christopher I. Amos,Amanda B. Spurdle,Deborah J. Thompson,Tracy A. O'Mara,Brian M. Wolpin,Laufey T. Amundadottir,Rachael Z. Stolzenberg-Solomon,Antonia Trichopoulou,N. Charlotte Onland-Moret,Eiliv Lund,Eric J. Duell,Federico Canzian,Gianluca Severi,Kim Overvad,Marc J. Gunter,Rosario Tumino,Ulrika Svenson,Andre M. van Rij,Annette F. Baas,Matthew J. Bown,Nilesh J. Samani,Femke N G van t'Hof,Gerard Tromp,Gregory T. Jones,Helena Kuivaniemi,James R. Elmore,Mattias Johansson,James McKay,Ghislaine Scelo,Robert Carreras-Torres,Valerie Gaborieau,Paul Brennan,Paige M. Bracci,Rachel E. Neale,Sara H. Olson,Steven Gallinger,Donghui Li,Gloria M. Petersen,Harvey A. Risch,Alison P. Klein,Jiali Han,Christian C. Abnet,Neal D. Freedman,Philip R. Taylor,John M. Maris,Katja K.H. Aben,Lambertus A. Kiemeney,Sita H. Vermeulen,John K. Wiencke,Kyle M. Walsh,Margaret Wrensch,Terri Rice,Clare Turnbull,Kevin Litchfield,Lavinia Paternoster,Marie Standl,Gonçalo R. Abecasis,John Paul SanGiovanni,Yong Li,Vladan Mijatovic,Yadav Sapkota,Siew-Kee Low,Krina T. Zondervan,Grant W. Montgomery,Dale R. Nyholt,David A. van Heel,Karen A. Hunt,Dan E. Arking,Foram N. Ashar,Nona Sotoodehnia,Daniel Woo,Jonathan Rosand,Mary E. Comeau,W. Mark Brown,Edwin K. Silverman,John E. Hokanson,Michael H. Cho,Jennie Hui,Manuel A. R. Ferreira,Philip J. Thompson,Alanna C. Morrison,Janine F. Felix,Nicholas L. Smith,Angela M. Christiano,Lynn Petukhova,Regina C. Betz,Xing Fan,Xuejun Zhang,Caihong Zhu,Carl D. Langefeld,Susan D. Thompson,Feijie Wang,Xu Lin,David A. Schwartz,Tasha E. Fingerlin,Jerome I. Rotter,Mary Frances Cotch,Richard A. Jensen,Matthias Munz,Henrik Dommisch,Arne S. Schaefer,Fang Han,Hanna Ollila,Ryan P. Hillary,Omar M. E. Albagha,Stuart H. Ralston,Chenjie Zeng,Wei Zheng,Xiao-Ou Shu,André Reis,Steffen Uebe,Ulrike Hüffmeier,Yoshiya Kawamura,Takeshi Otowa,Tsukasa Sasaki,Martin L. Hibberd,Sonia Davila,Gang Xie,Katherine A. Siminovitch,Jin-Xin Bei,Yi Xin Zeng,Asta Försti,Bowang Chen,Stefano Landi,Andre Franke,Annegret Fischer,David Ellinghaus,Carlos Flores,Imre Noth,Shwu-Fan Ma,Jia Nee Foo,Jianjun Liu,Jong-Won Kim,David G. Cox,Olivier Delattre,Olivier Mirabeau,Christine F. Skibola,Clara S. Tang,Merce Garcia-Barcelo,Kai-Ping Chang,Wen-Hui Su,Yu-Sun Chang,Nicholas G. Martin,Scott D. Gordon,Tracey D. Wade,Chaeyoung Lee,Michiaki Kubo,Pei-Chieng Cha,Yusuke Nakamura,Daniel Levy,Masayuki Kimura,Shih-Jen Hwang,Steven C. Hunt,Tim D. Spector,Nicole Soranzo,Ani Manichaikul,R. Graham Barr,Bratati Kahali,Elizabeth K. Speliotes,Laura M. Yerges-Armstrong,Ching-Yu Cheng,Jost B. Jonas,Tien Yin Wong,Isabella Fogh,Kuang Lin,John Powell,Kenneth Rice,Caroline L Relton,Richard M. Martin,George Davey Smith +197 more
TL;DR: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases, as well as single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population.
Journal ArticleDOI
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Yukinori Okada,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Takahisa Kawaguchi,Eli A. Stahl,Eli A. Stahl,Fina A S Kurreeman,Fina A S Kurreeman,Fina A S Kurreeman,Nao Nishida,Hiroko Ohmiya,Keiko Myouzen,Meiko Takahashi,Tetsuji Sawada,Yuichi Nishioka,Masao Yukioka,Tsukasa Matsubara,Shigeyuki Wakitani,Ryota Teshima,Shigeto Tohma,Kiyoshi Takasugi,Kota Shimada,Akira Murasawa,Shigeru Honjo,Keitaro Matsuo,Hideo Tanaka,Kazuo Tajima,Taku Suzuki,Takuji Iwamoto,Yoshiya Kawamura,Hisashi Tanii,Yuji Okazaki,Tsukasa Sasaki,Peter K. Gregersen,Leonid Padyukov,Jane Worthington,Katherine A. Siminovitch,Mark Lathrop,Atsuo Taniguchi,Atsushi Takahashi,Katsushi Tokunaga,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani,Tsuneyo Mimori,Robert M. Plenge,Robert M. Plenge,Hisashi Yamanaka,Shigeki Momohara,Ryo Yamada,Fumihiko Matsuda,Kazuhiko Yamamoto +54 more
TL;DR: This study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10−8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2.
Journal ArticleDOI
Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.
Chihiro Kakiuchi,Kazuya Iwamoto,Mizuho Ishiwata,Miki Bundo,Takaoki Kasahara,Ichiro Kusumi,Takahiro Tsujita,Yuji Okazaki,Shinichiro Nanko,Hiroshi Kunugi,Tsukasa Sasaki,Tadafumi Kato +11 more
TL;DR: Results indicate that the −116C→G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder.
Journal ArticleDOI
Association of the oxytocin receptor ( OXTR ) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population
Xiaoxi Liu,Yoshiya Kawamura,Takafumi Shimada,Takeshi Otowa,Shinko Koishi,Toshiro Sugiyama,Hisami Nishida,Ohiko Hashimoto,Ryoichi Nakagami,Mamoru Tochigi,Tadashi Umekage,Yukiko Kano,Taku Miyagawa,Nobumasa Kato,Katsushi Tokunaga,Tsukasa Sasaki +15 more
TL;DR: This study might support that OXTR has a significant role in conferring the risk of ASD in the Japanese population by analyzing 11 single-nucleotide polymorphisms (SNPs) using both family-based association test (FBAT) and population-based case–control test.
Journal ArticleDOI
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.
Toshio Munesue,Shigeru Yokoyama,Kazuhiko Nakamura,Ayyappan Anitha,Kazuo Yamada,Kenshi Hayashi,Tomoya Asaka,Hong-Xiang Liu,Duo Jin,Keita Koizumi,Mohammad Saharul Islam,Jian-Jun Huang,Wen Jie Ma,Uh-Hyun Kim,Sun Jun Kim,Keunwan Park,Dongsup Kim,Mitsuru Kikuchi,Yasuki Ono,Hideo Nakatani,Shiro Suda,Taishi Miyachi,Hirokazu Hirai,Alla B. Salmina,Yu A. Pichugina,Andrei A. Soumarokov,Nori Takei,Norio Mori,Masatsugu Tsujii,Toshiro Sugiyama,Kunimasa Yagi,Masakazu Yamagishi,Tsukasa Sasaki,Hidenori Yamasue,Nobumasa Kato,Ryota Hashimoto,Masako Taniike,Yutaka Hayashi,Jun-ichiro Hamada,Shioto Suzuki,Akishi Ooi,Mami Noda,Yuko Kamiyama,Mizuho A. Kido,Olga Lopatina,Minako Hashii,Sarwat Amina,Fabio Malavasi,Eric J. Huang,Jiasheng Zhang,Nobuaki Shimizu,Takeo Yoshikawa,Akihiro Matsushima,Yoshio Minabe,Haruhiro Higashida +54 more
TL;DR: The immunohistochemical expression of CD38 in the hypothalamus of post-mortem brains of non-ASD subjects is examined and it is found that CD38 was colocalized with OT in secretory neurons.